Cyclizine Flashcards
1
Q
What is the MOA of cyclizine?
A
Competitive antagonist at H1 and muscarinic receptors
2
Q
What is the absorption/distribution of cyclizine?
A
- well absorbed orally
- oral bioavailibility 75%
- half life 10hrs
3
Q
What are the GI SEs of cyclizine?
A
Increased lower oesophageal sphincter tone
4
Q
What are the CVS SEs of cyclizine?
A
Tachycardia
5
Q
What are the general SEs of cyclizine?
A
- pain on injection because pH of solution is 3.2
- mild sedation
6
Q
What is the metabolism and excretion of cyclizine?
A
- hepatic metabolism
- decrease dose in liver failure
- excreted in urine
7
Q
What is the dose of cyclizine?
A
50mg 8hrly (adults)
1mg/kg 8hrly (kids)
8
Q
A
