Atropine Flashcards
1
Q
What is atropine?
A
Synthetic tertiary amine
2
Q
What is the dose of atropine?
A
600mcg in 1 ml 200mcg - 600 mcg. Usually 300mcg for arrests titrated up to 1200mcg.
3
Q
What is the MOA of atropine?
A
Competitive antagonist at muscarinic receptors
4
Q
What is the absorption/distribution of atropine?
A
- Well absorbed orally (10-25% oral bioavailibility)
- Protein binding 50%
- Volume of distribution 2-4 L/kg
5
Q
What are the uses of atropine?
A
- premed to decrease secretions
- treat bradycardias
- in ALS algorithm for PEA/asystole
- treatment of organophosphate poisoning
6
Q
What are the CVS effects of atropine?
A
- tachycardia
- effect lasts 2-3hrs
- may precipitate arrhythmias by decreasing AV conduction time
7
Q
What are the RS effects of atropine?
A
- bronchodilation
- increased RR
8
Q
What are the CNS effects of atropine?
A
- crosses BBB causing central anticholinergic syndrome
- antiemetic
- antiparkinsonian effects
9
Q
What are the GI effects of atropine?
A
- antisialogogue
- decreases tone of lower oesophageal sphincter
10
Q
What are the metabolic effects of atropine?
A
Inhibits sweating - may cause hyperpyrexia in children
11
Q
What are the antimuscarinic effects of atropine?
A
- dry mouth
- blurred vision
- urinary retention
12
Q
What are the chemical properties of atropine?
A
- Racemic mixture of D and L atropine
- Only L is active
