Bupivicaine Flashcards
1
Q
What is bupivicaine?
A
AMIDE local anaesthetic
2
Q
What forms does bupivicaine come in?
A
2 isomers:
- levobupivicaine (single isomer)
- bupivacaine(racemic mix of R and S enantiomers)
3
Q
What is the pKa of bupivicaine?
A
8.1
4
Q
What is the does of bupivicaine?
A
2mg/kg
5
Q
What are the SEs of bupivicaine?
A
- myocardial depression
- CNS convulsions then coma (levobupivacaine less toxic)
6
Q
What are the CI to bupivacaine?
A
- allergy
- Bier’s block (IVRA)
7
Q
What is the metabolism of bupivacaine?
A
Metabolised in the liver by hepatic amidases.
8
Q
What is the protein binding if bupivacaine?
A
95% protein bound
9
Q
What is bupivacaine used for?
A
- local nerve blocks + infiltration
- regional anaesthesia and analgesia
- obstetrics
10
Q
What are the characteristics of bupivacaine?
A
- lipid soluble
- colourless solution (0.25% or 0.5% or also with 5% glucose as Marcain)
- slow onset (30mins)
- long duration (2-6hrs)
11
Q
A
