Ondansetron

Question 1

Pharmacology & Actions

Answer 1

• Selectively blocks serotonin 5-HT3 receptors in the brain
• Primary effect is in the GI tract
• No effect on dopamine receptors, therefor does not cause extrapyramidal symptoms (drug induced movement disorder)

Question 2

Indications

Answer 2

Nausea or Vomiting

Question 3

Absolute Contraindications

Answer 3

• prolonged QT
• Patients <1month old
• allergy

Question 4

Precautions and Side Effects

Answer 4

May cause prolonged QT, do not use with patients who have prolonged QT syndrome

Question 5

Administration

Answer 5

• IV/IO/PO/SL
• Onset of 10-30min
• Peak 1.5hrs
• Duration 8hrs
• Dose 4mg