Oncology (cancer) Flashcards

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1
Q

oncos

A

benign tumor, slow growth, encapsulated

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2
Q

carcinos

A

malignant tumor, fast growth, invasive/infiltrative, anaplastic, metastatic

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3
Q

neoplasm

A

tumor의 다른 명칭

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4
Q

주변조직 침범여부에 따른 분류 3가지

A

encapsulated(피막형성), invasive(침습성), infiltrative(침윤성)

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5
Q

invasive와 infiltrative 차이

A

invasive: enter and destroy surrounding tissue
infiltrative: extending beyond normal tissue boundaries

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6
Q

morphology 용어 2가지

A

anaplasia(역형성의), hyperchromatic(과다염색의)

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7
Q

location 용어 1가지

A

metastatic(전이)

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8
Q

발암유발 인자 2가지

A

environmental agents, heredity

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9
Q

environmental agents 종류 3가지

A

chemical carcinogens, radiation, oncogenic viruses

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10
Q

chemical carcinogens 종류 3가지

A

hydrocarbons, hormones, insecticides

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11
Q

oncogene 뜻 및 4가지

A

종양유전자, RAS(colon cancer), ABL(chronic myelogenous leukemia), MYC(lymphoma), PML-RARA

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12
Q

heredity 특징 및 종류 4가지

A

tumor suppresor genes, BRCA(ovarian, breast), APC(polyposis coli syndrome), p53(Li-fraumeni, 최빈), Rb1(retinoblastoma, 최초발견)

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13
Q

oncogene vs TSG

A

oncogene = gain of function, TSG = loss of function

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14
Q

cancerous tumors 분류 기준

A

histogenesis(조직발생)의 기원 세포 종류

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15
Q

cancerous tumors 3가지 및 유래조직

A

carcinoma(epithelial), sarcoma(connective), mixed-tissue tumors(미분화 세포, 특히 줄기세포)

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16
Q

carcinoma 2가지

A

adenoma(샘종, 양성), adenocarcinoma(샘암종, 악성)

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17
Q

sarcoma 유래 조직의 3가지 이름

A

기원: mesodermal layer(중배엽)
구성: mesenchymal tissue(중간엽 조직)
역할: parenchyme(실질)

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18
Q

sarcoma 7가지

A

osteosarcoma, osteoma, leukemia, lymphoma, giloma, neuroblastoma, rhabadomyosarcoma

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19
Q

mixed-tissue tumor 2가지와 위치

A

Wilms tumor (kidney), Teratoma (ovaries, testes)

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20
Q

pathologic description 2가지와 경우

A

gross(클 때), microscopic(작을 때)

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21
Q

gross description 7가지

A

cystic, fungating, inflammatory, medullary, necrotic, polypoidy, ulcerating

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22
Q

cystic 2가지

A

mucinous(점액성), serous(장액성)

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23
Q

fungating

A

버섯 모양의

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24
Q

polypoidy

A

폴립 모양

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25
Q

microscopic description 10가지

A

alveolar, carcinoma in situ, diffuse, dysplastic, epidermoid, follicular, papillary, pleomorphic, scirrhous, undifferentiated

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26
Q

alevolar

A

꽈리의

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27
Q

carcinoma in situ

A

상피내암종, 그 자리에 그냥 있는 것

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28
Q

diffuse

A

spreading evenly throughout

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29
Q

dysplastic

A

형성이상

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30
Q

epidermoid

A

표피유사

31
Q

follicular

A

소포, 난포, 주머니

32
Q

pleomorphic

A

다형의, 다형태의

33
Q

scirrhous

A

굳은암종의

34
Q

grading system 기준 및 등급

A

현미경으로 볼 때 분화 정도, I, II, III, IV 순으로 분화가 비정상

35
Q

staging system 기준 및 등급

A

퍼져나간 정도, TNM 점수, I, II, III, IV 순으로 전이가 많이 되어 치료가능성 나쁨

36
Q

TNM 점수

A

T: primary tumor의 크기, 기준 3cm
N: regional lymph node에 전이여부
M: distant metastasis, 멀리 전이여부

37
Q

cancer treatment 4가지

A

surgery, radiation therapy, chemotherapy, biological therapy

38
Q

surgery 9가지

A

debulking, adjuvant, cauterization, cryosurgery, en bloc resection, excisional biopsy, incisional biopsy, exenteration, fulguration

39
Q

adjuvant

A

radiation and/or chemotherapy 보조

40
Q

cryosurgery

A

freeze and destroy tissue

41
Q

en blog resection

A

일괄절제술, surrounding tissue containing lymph nodes is removed as well

42
Q

excisional biopsy

A

removal of tumor and margin of normal tissue

43
Q

incisional biopsy

A

removal of piece of tumor to establish diagnosis

44
Q

exenteration

A

내용물적출술, removes organ of origin as well as tumor

45
Q

fulguration

A

destruction of tissue via electricity

46
Q

radiation therapy 8가지

A

brachytherapy, fractionation, gray(Gy, rad), photon therapy, proton therapy, radiosensitizers, simulation, stereotactic radiosurgery

47
Q

brachytherapy

A

근접치료

48
Q

fractionation

A

small repeated doses instead of large doses

49
Q

gray(Gy)

A

unit of absorbed radiation dose

50
Q

photon therapy

A

uses x-rays of gamma rays

51
Q

radiosensitizers

A

방사선민감화약제

52
Q

stereotactic radiosurgery

A

gamma knife surgery using stereotactic(highly precise) guidance to destroy tumors

53
Q

radiotherapy 부작용 7가지

A

alopecia, fibrosis, mucositis, myelosuppresion, nausea/vomiting, pneumonitis, xerostomia

54
Q

alopecia

A

탈모

55
Q

fibrosis

A

섬유종

56
Q

mucositis

A

점막염

57
Q

myelosuppresion

A

골수분화억제

58
Q

pneumonitis

A

폐렴

59
Q

xerostomia

A

구강건조증

60
Q

chemotherapy 5가지

A

alkylating agents, antibiotics, antimetabolites, antimiotics, hormonal agents

61
Q

alkylating agents 3가지

A

carmustine, cisplatin, temozolomide

62
Q

antibiotics 1가지 및 암 종류

A

doxorubicin (breast cancer)

63
Q

antimetabolites 3가지

A

cytarabine, 5-FU(5-Fluorouracil), MTX(methotrexate)

64
Q

antimitotics 1가지

A

paclitaxel (taxol)

65
Q

hormonal agents 3가지

A

dexamethasone, prednisone, tamoxifen

66
Q

biological therapy 원리 및 4가지

A

biological response modifiers 이용, bevacizumab, interferons, interleukin2, trastuzumab

67
Q

cancer treatment drugs 2가지

A

molecularly targeted drugs, differentiating agents

68
Q

molecularly targeted drugs 2가지

A

angiogenesis 표적 drug, Abl kinase 표적 drug

69
Q

angiogenesis 표적 drug 2가지

A

bevacizumab: mAb, VEGF(growth factor) 파괴
sunitinib: nib(inhibitor), VEFG receptor를 억제

70
Q

Abl kinase 표적 drug 1가지

A

Imatinib(Gleevec): abl oncogene이 발현 후 일종의 kinase로 작용하는 것을 억제

71
Q

differentiating agents 1가지 및 치료 암

A

ATRA(all trans retinoic acid)로 APL(acute promyelocytic leukemia) 치료

72
Q

lab test 원리 및 1가지

A

혈액 속 protein을 측정해 암 진단, PSA(prostate-specific antigen)

73
Q

clinical procedures 5가지

A

bone marrow biopsy, bone marrow or stem cell transplant, exfoliative cytology(pap smear test), laparoscopy aka peritoneoscopy, mammography