Oncology 7-9%

Question 1

Antimetabolites
1) MOA
2) Examples
3) Side effects / toxicities

Answer 1

1) Block S phase of cell cycle by mimicking normal purines and pyrimidines
2) methotrexate, cytosar (cytosine arabinoside), 5-flurouracil, azathioprine, hydroxyurea
3) myelosupresion, GI

Question 2

Vinca Alkaloids
1) MOA
2) Examples
3) side effects / toxicities

Answer 2

1) Block M phase of the cell cycle by interfering with microtubule formation - metaphase arrest
2) Examples - Vincristine, Vinblastine, Vinorelbine
3) Myelosupression, GI, Metabolized by liver, Vesicants

MDR 1 drugs

Question 3

Vincristine
1) indications
2) side effects

Answer 3

1) lymphoma, leukemia, TVT
2) GI, bone marrow, perioheral neuropathy (ataxia, ileus)

Question 4

Vinblastine
1) indications
2) side effects

Answer 4

1) MCT, TCC, lymohoma / leukemia
2) GI, bone marrow

Question 5

Vinorelbine
1) indications
2) side effects

Answer 5

1) pulmonary adenocarcinoma
2) GI, bine marrow

Question 6

What is Gompertzian growth of tumour cells

Answer 6

Small tumours grow faster than large ones and rapidly dividing cells are more responsive to chemo

Grow is slowest at the end of time period

Question 7

Platelet dysfunction is associated with which condition

Answer 7

Multiple myeloma

Question 8

Older dog with abdominal pain and moderate hypoglycemia. Bloodwork otherwise normal, imaging shows mass of cardia of the stomach. Most likely diagnosis

Answer 8

Leiomyosarcoma

Question 9

Collie waiting to ABCD1 mutation test, diagnosed with lymphoma, 3yr. Which drug to use while waiting ?

Answer 9

Cyclophos