Toxicology 3-5%

Question 1

Which of the following is not responsive to o2 therapy
A) PTE
B) cyqnide toxicity
C) chronic bronchitis
D) bacterial pneumonia

Answer 1

Cyanide toxicity or shunts (xtreme ventilation perfusion mismatch or anatomic right to left shunts)

Question 2

Forst line treatment for xylitol toxicity
A) dextrose supplementation
B) lactulose enema

Answer 2

Dextrose

Question 3

Poodle with 24hr vomiting, diarrhoea, weakness, anorexia
Bloods: normal glu, normal bun, albumin 2.7, alt 600, alkp 200, ggt increased, bili 2.5
Likely toxicity
A) aflatoxicosis
B) minoxidyl
C) carbamate
D) xylitol

Answer 3

Aflatoxicosis

Question 4

Best early test for rodenticide toxicity

Answer 4

Protein inducers of vit K antagonists (PIVKA) (+PT)

Question 5

What exacerbates digoxin toxicity

Answer 5

Hypokalaemia

Question 6

What is the effect of botulin toxin on NMJ ? (how does it affect Ach release?)

Answer 6

Cleave synaptin so stops Ach vesicle fusion and no release

Question 7

How does tetanus antitoxin work ?

Answer 7

Bind / neutralize any freeor unbound toxin (tetanospasmin)

Question 8

Dog with clinical signs of bradycardia and urine dribbling – most likely toxin ?

Answer 8

Marijuana

Question 9

Dog with anemia and generalized tremors, most likely toxin ?

Answer 9

Mycotoxin