Immunology 7-9%

Question 1

Rattle snake poisoning, type of hypersensitivity after day 10

Answer 1

Antivenom can cause type I (immediate) or type III (immune complex mediated) - ‘serum sickness’

Question 2

Lupus attacks which
A) cell membrane
B) nucleus
C) mitochondria

Answer 2

B) nucleus

Question 3

Most common clinical signs of lupus erythematosus

Answer 3

Fever (constant or cyclic)
Polyarthritis (non erosive, non deforming)
Proteinuria
Skin dz

Question 4

IL-4, 13, 10 cause macrophages to become what
A) M1
B) M2
C) NK cells
D) T0 cells

Answer 4

M2

Question 5

Outline function of NK cells

Answer 5

Recruited by IL12 produced by macrophages
Produce IFN gamma which activates macrophages - positive feedback
Triggers to kill

Question 6

NK cellcs produce which of the following in abundance
A) IFN alpha
B) iFN gamma
C) other

Answer 6

IFN gamma

Question 7

What cytokine stimulates eosinophile activity

Answer 7

IL-5

Question 8

What leukotriene attracts neutrophils

Answer 8

B4 (LTB4)

Question 9

Which cytokines are pyrogens ?

Answer 9

TNF – alpha and beta, IL6, IL1, IFN alpha