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NAPLEX > Oncology > Flashcards

Oncology Flashcards

1
Q

Nitrosoureas cause what toxicity?

A

Neurotoxicity

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2
Q

Nitrosourea examples

A

lomustine, carmustine

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3
Q

Platinum-based chemo meds cause what toxicities?

A

nephrotoxicity, peripheral neuropathy, vomiting

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4
Q

Platinum-based med examples

A

Carboplatin, cisplatin

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5
Q

MTX, 5-FU, and capcitabine cause what toxicity?

A

Mucositis

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6
Q

Bleomycin, busulfan, carmustine, lomustine cause what toxicity?

A

Pulmonary fibrosis

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7
Q

Anthracyclines cause what toxicity?

A

Cardiotoxicity

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8
Q

Anthracycline examples

A

Doxorubicin, daunorubicin

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9
Q

Immunotherapy for cancer causes what toxicity?

A

Autoimmune syndromes

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10
Q

Examples of immunotherapy for cancer

A

ipilimumab, atezolizumab, pembrolizumab

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11
Q

Ifosfamide and cyclophosphamide cause what toxicity?

A

Hemorrhagic cystitis

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12
Q

Vinca alkaloids cause what toxicity?

A

peripheral neuropathy

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13
Q

Examples of vinca alkaloids

A

vincristine, vinblastine, vinorelbine

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14
Q

Taxanes cause what toxicity?

A

peripheral neuropathy

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15
Q

Examples of taxanes

A

paclitaxel, docetaxel

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16
Q

What chemo meds cause bone marrow suppression?

A

Most of them, EXCEPT bleomycin, pegaspargase, vincristine

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17
Q

Irinotecan causes what toxicity?

A

DIARRHEA

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18
Q

Chemo-adjunctive treatment: what to give with cisplatin

A

amifostine and hydration

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19
Q

What do amifostine and hydration do to help with cisplatin treatment?

A

Prevent neurotoxicity

20
Q

Chemo-adjunctive treatment: what to give with doxorubicin

A

dexrazozane

21
Q

Purpose of dexarzozane in doxorubicin treatment

A

Prevent cardiotoxicity

22
Q

Chemo-adjunctive treatment: what to give with 5-FU

A

leucovorin, levoleucovorin

23
Q

Purpose of leucovorin/levoleucovorin with 5-FU

A

enhance efficacy

24
Q

Antidote for 5-FU

A

uridine triacetate- give within 96 hours

25
Q

Chemo-adjunctive treatment: what to give with ifosfamide

A

mesna

26
Q

Purpose of mesna with ifosfamide treatment

A

prevent hemorrhagic cystitis

27
Q

Antidote for capecitabine

A

uridine triacetate

28
Q

Chemo-adjunctive treatment: what to give with irinotecan

A

atropine, loperamide

29
Q

Purpose of atropine and loperamide with irinotecan

A

Atropine for acute diarrheal episodes
loperamide for delayed diarrheal episodes

30
Q

Chemo-adjunctive treatment: what to give with MTX

A

leucovorin, levoleucovorin

31
Q

Purpose of leucovorin/levoleucovorin with MTX

A

protect the cells from toxicity after high-dose MTX

32
Q

MTX antidote

A

glucarpidase, give within 48-60 hours

33
Q

Extravasation treatment: anthracyclines

A

COLD compresses, give dexrazozane/dimethyl sulfoxide

34
Q

Extravasation treatment: vinca alkaloids

A

WARM compresses, give hyaluronidase

35
Q

Max doses: bleomycin

A

cumulative lifetime dose of 400 units

36
Q

Max doses: doxorubicin

A

cumulative lifetime dose of 450-550mg/m2

37
Q

Max doses: cisplatin

A

100mg/m2/cycle

38
Q

Max doses: vincristine

A

single dose capped at 2mg

39
Q

What route should you NOT give vincristine

A

Intrathecally (duh)

40
Q

TLS management

A

Aggressive IV hydration
electrolyte correction as needed
urate lowering treatment: allopurinol, rasburicase

41
Q

Hypercalcemia of malignancy treatment

A

hydration with NS
Calcitonin
IV bisphosphonates: Zometa (zoledronic acid)
Denosumab (Xgeva)

42
Q

CINV treatment: high emetic risk

A

NK1-RA+5HT3 RA+olanzapine+dexamethasone

43
Q

CINV treatment: moderate emetic risk

A

NK1-RA+5HT3 RA+ dexamethasone

44
Q

CINV treatment: low emetic risk

A

One drug (as long as it’s not Emend): dexamethasone, prochlorperazine, metoclopramide

45
Q

CINV treatment: minimal emetic risk

A

no routine prophylaxis needed

NAPLEX (18 decks)

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