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NAPLEX > Autoimmune Disease Drugs (Specialty Pharmacy Drugs) > Flashcards

Autoimmune Disease Drugs (Specialty Pharmacy Drugs) Flashcards

1
Q

JAK inhibitors for RA

A

tofacitinib, baricitnib, updadacitnib

(basically anything that ends in -nib)

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2
Q

TNF alpha inhibitors used for RA

A

Enbrel, Humira, Remicade, Cimzia, Simponi

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3
Q

Rituximab MoA

A

Depletes CD20 cells

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4
Q

Anakira MoA

A

IL-1 receptor antagonist

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5
Q

Orencia MoA

A

Binds to CD80 and CD86 and inhibits T-cell activation

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6
Q

Actemra MoA

A

IL-6 receptor antagonist

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7
Q

Kevzara MoA

A

IL-6 receptor antagonist

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8
Q

Drugs that can cause DILE

A

methimazole
propothiouracil
methyldopa
minocycline
procainamide
hydralazine
anti-TNF agents
terbinafine
isoniazid
quinidine

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9
Q

Benlysta MoA

A

IgG1-lambda monoclonal antibody; prevents B lymphocyte survival

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10
Q

Voclosporin MoA

A

calcineurin inhibitor

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11
Q

Copaxone MoA

A

thought to induce and activate T-lymphocytes suppressor cells in relapsing forms of MS

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12
Q

Interferon products used for MS

A

Avonex, Plegridy, Betaseron

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13
Q

S1P receptor modulators used in MS

A

Gilenya, Zeposia, Ponvory, Mayzent

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14
Q

S1P receptor modulator that requires genomic testing

A

Mayzent

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15
Q

Fingolimod (Gilenya) monitoring

A

Requires an ECG at baseline and at end of initial observation period because it can cause bradycardia and other bradyarrhythmias

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16
Q

S1P receptor modulator MoAs

A

Blocks lymphocytes from leaving the lymph nodes

17
Q

Nrf2 activators used in MS

A

Dimethyl fumarate
Diroximel fumarate
Monomethyl fumarate

18
Q

Aubagio MoA

A

pyrimidine synthesis inhibitor

19
Q

Kesimpta, Briumvi, Ocrevus MoAs

A

CD20-directed Mabs

20
Q

Lemtrada MoA

A

CD52-directed cytolytic Mab

21
Q

Tysabri MoA

A

Mab that binds to the alpha-4 subunit of integrin molecules

22
Q

Mavenclad BBW

A

malignancies, teratogenicity

23
Q

Mavenclad CI

A

seizures

24
Q

Ampyra- what does it do?

A

Improve walking speeds in MS patients

25
Q

Neudexta- what does it do?

A

Helps with PBA in MS patients

26
Q

Preferred MS treatment in pregnant patients

A

Copaxone

27
Q

Retinoid for systemic psoriasis

A

Acitretin

28
Q

PDE4i for systemic psoriasis

A

Otezla

29
Q

Interleukin receptor antagonists for systemic psoriasis

A

Siliq
Tremfya
Taltz
Skyrizi
Cosentyx
Ilumya
Stelara

30
Q

Selective tyrosine kinase 2 inhibitor for systemic psoriasis

A

Sotyktu

NAPLEX (18 decks)

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