Autoimmune Disease Drugs (Specialty Pharmacy Drugs) Flashcards
(30 cards)
JAK inhibitors for RA
tofacitinib, baricitnib, updadacitnib
(basically anything that ends in -nib)
TNF alpha inhibitors used for RA
Enbrel, Humira, Remicade, Cimzia, Simponi
Rituximab MoA
Depletes CD20 cells
Anakira MoA
IL-1 receptor antagonist
Orencia MoA
Binds to CD80 and CD86 and inhibits T-cell activation
Actemra MoA
IL-6 receptor antagonist
Kevzara MoA
IL-6 receptor antagonist
Drugs that can cause DILE
methimazole
propothiouracil
methyldopa
minocycline
procainamide
hydralazine
anti-TNF agents
terbinafine
isoniazid
quinidine
Benlysta MoA
IgG1-lambda monoclonal antibody; prevents B lymphocyte survival
Voclosporin MoA
calcineurin inhibitor
Copaxone MoA
thought to induce and activate T-lymphocytes suppressor cells in relapsing forms of MS
Interferon products used for MS
Avonex, Plegridy, Betaseron
S1P receptor modulators used in MS
Gilenya, Zeposia, Ponvory, Mayzent
S1P receptor modulator that requires genomic testing
Mayzent
Fingolimod (Gilenya) monitoring
Requires an ECG at baseline and at end of initial observation period because it can cause bradycardia and other bradyarrhythmias
S1P receptor modulator MoAs
Blocks lymphocytes from leaving the lymph nodes
Nrf2 activators used in MS
Dimethyl fumarate
Diroximel fumarate
Monomethyl fumarate
Aubagio MoA
pyrimidine synthesis inhibitor
Kesimpta, Briumvi, Ocrevus MoAs
CD20-directed Mabs
Lemtrada MoA
CD52-directed cytolytic Mab
Tysabri MoA
Mab that binds to the alpha-4 subunit of integrin molecules
Mavenclad BBW
malignancies, teratogenicity
Mavenclad CI
seizures
Ampyra- what does it do?
Improve walking speeds in MS patients
