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NAPLEX > Liver Disease > Flashcards

Liver Disease Flashcards

1
Q

BBW for all DAAs

A

risk of reactivating HBV

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2
Q

Mayvret

A

glecaprevir/pibrentasvir

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3
Q

Epclusa

A

sofosbuvir/velpatasvir

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4
Q

Harvoni

A

sofosbuvir/ledipasvir

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5
Q

Vosevi

A

sofosbuvir/velpatasvir/voxilaprevir

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6
Q

Zepatier

A

elbasvir/grazoprevir

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7
Q

HCV treatments approved for all HCV genotypes

A

Epclusa, Mayvret

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8
Q

HCV treatment approved for 8 week course

A

Mayvret

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9
Q

HCV treatment approved for salvage therapy

A

Vosevi and Mayvret

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10
Q

DAAs are CI’ed with what?

A

CYP3A4 inducers

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11
Q

When can ribavirin be used in HCV?

A

Add-on treatment to DAAs

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12
Q

BBW for ribavirin

A

teratogenicity, hemolytic anemia, not effective as monotherapy

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13
Q

CIs for ribavirin

A

pregnancy, male partners of pregnant women

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14
Q

When to avoid pregnancy when taking ribavirin

A

during therapy and 6 months after; use 2 reliable forms of contraception

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15
Q

BBW for all HBV NRTIs

A

lactic acidosis and severe hepatomegaly with steatosis

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16
Q

TDF

A

Viread

17
Q

TAF

A

Vemlidy

18
Q

All HBV NRTIs need dose adjustment when?

A

CrCl <50

19
Q

Warnings for tenofovir

A

renal toxicity, Fanconi syndrome, osteomalacia, decreased bone mineral density

20
Q

Entecavir

A

Baraclude

21
Q

Baraclude counseling point

A

Take on an empty stomach

22
Q

Lamivudine

A

Epivir HBV (HIV one is just Epivir)

23
Q

Epivir HBV side effects

A

N/V/D, HA

24
Q

Pegasys BBW

A

Can cause or exacerbate neuropsychiatric, autoimmune, ischemic, or infectious disorders

Teratogenic risk if used with ribavirin

25
Q

Pegasys side effects

A

CNS effects, increased LFTs, GI upset, flu-like syndrome (can pre-treat)

26
Q

Vasoconstriction medications for bleeding varices

A

Octreotide
Vasopressin

27
Q

Meds for portal HTN

A

Nadolol
Propranolol
Carvedilol

These are all non-selective!

28
Q

Meds for hepatic encephalopathy

A

lactulose, rifaximin

29
Q

Meds for ascites

A

diuretic therapy: spironolactone monotherapy or furosemide WITH spironolactone

30
Q

Ratio of spironolactone:furosemide for ascites

A

100mg:40mg

31
Q

SBP treatment

A

CTX x5-7 days

32
Q

SBP prophylaxis treatment

A

Bactrim or cipro

33
Q

SBP hepatorenal syndrome treatment

A

albumin, octreotide, midodrine

34
Q

Preferred HCV treatments

A

2-3 DAAs with different MOAs

NAPLEX (18 decks)

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