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NAPLEX > Liver Disease > Flashcards

Liver Disease Flashcards

1
Q

BBW for all DAAs

A

risk of reactivating HBV

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2
Q

Mayvret

A

glecaprevir/pibrentasvir

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3
Q

Epclusa

A

sofosbuvir/velpatasvir

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4
Q

Harvoni

A

sofosbuvir/ledipasvir

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5
Q

Vosevi

A

sofosbuvir/velpatasvir/voxilaprevir

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6
Q

Zepatier

A

elbasvir/grazoprevir

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7
Q

HCV treatments approved for all HCV genotypes

A

Epclusa, Mayvret

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8
Q

HCV treatment approved for 8 week course

A

Mayvret

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9
Q

HCV treatment approved for salvage therapy

A

Vosevi and Mayvret

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10
Q

DAAs are CI’ed with what?

A

CYP3A4 inducers

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11
Q

When can ribavirin be used in HCV?

A

Add-on treatment to DAAs

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12
Q

BBW for ribavirin

A

teratogenicity, hemolytic anemia, not effective as monotherapy

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13
Q

CIs for ribavirin

A

pregnancy, male partners of pregnant women

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14
Q

When to avoid pregnancy when taking ribavirin

A

during therapy and 6 months after; use 2 reliable forms of contraception

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15
Q

BBW for all HBV NRTIs

A

lactic acidosis and severe hepatomegaly with steatosis

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16
Q

TDF

17
Q

TAF

18
Q

All HBV NRTIs need dose adjustment when?

19
Q

Warnings for tenofovir

A

renal toxicity, Fanconi syndrome, osteomalacia, decreased bone mineral density

20
Q

Entecavir

21
Q

Baraclude counseling point

A

Take on an empty stomach

22
Q

Lamivudine

A

Epivir HBV (HIV one is just Epivir)

23
Q

Epivir HBV side effects

24
Q

Pegasys BBW

A

Can cause or exacerbate neuropsychiatric, autoimmune, ischemic, or infectious disorders

Teratogenic risk if used with ribavirin

25
Pegasys side effects
CNS effects, increased LFTs, GI upset, flu-like syndrome (can pre-treat)
26
Vasoconstriction medications for bleeding varices
Octreotide Vasopressin
27
Meds for portal HTN
Nadolol Propranolol Carvedilol These are all non-selective!
28
Meds for hepatic encephalopathy
lactulose, rifaximin
29
Meds for ascites
diuretic therapy: spironolactone monotherapy or furosemide WITH spironolactone
30
Ratio of spironolactone:furosemide for ascites
100mg:40mg
31
SBP treatment
CTX x5-7 days
32
SBP prophylaxis treatment
Bactrim or cipro
33
SBP hepatorenal syndrome treatment
albumin, octreotide, midodrine
34
Preferred HCV treatments
2-3 DAAs with different MOAs

NAPLEX (18 decks)

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