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ABSITE > Oncology > Flashcards

Oncology Flashcards

1
Q

Molecule leading to cachexia by increased catabolism and insulin resistance

A

TNF

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2
Q

Testing for all newly diagnosed colon cancers

A

Mismatch repair, Microsatellite instability

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3
Q

Risk factor for hepatic angiosarcoma

A

Vinyl chloride

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4
Q

Management of carcinoid tumors

A

Surgical excision

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5
Q

Management of metastatic carcinoid

A

Surgical debulking, IR embolization, somatostatin analogs (lanreotide), chemo

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6
Q

Medullary thyroid cancer in young patient with family hx; screening

A

Screen for MEN IIA/IIIB

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7
Q

Colorectal cancer starting on EGFR; tumor marker and treatment

A

KRAS testing for wild type, cetuximab

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8
Q

Positive PET mediastinum for melanoma; next step

A

Mediastinal exploration/bx due to 10-20% false positive rate

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9
Q

Most common location somatostatinomas

A

Head of pancreas

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10
Q

Prognostic factors for GIST

A

Tumor size and mitotic rate (less than 2cm and <5 low risk)

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11
Q

Alkylating agents (Oxaliplatin and Carboplatin); MOA

A

Directly damage DNA

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12
Q

Taxol (paclitaxel); MOA

A

Microtubule stabilization

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13
Q

Irinotecan, doxorubicin, etoposide; MOA

A

Topoisomerase inhibitors

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14
Q

Chlorambucil, cyclophosphamide, streptozocin; MOA

A

DNA alkylation

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15
Q

Vincristine, vinblastine; MOA

A

arrest cell in metaphase, disrupt mitotic spindle

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16
Q

Berberine, ethidium, bromide, proflavine, daunomycin, doxorubicin, thalidomide; MOA

A

DNA intercalators

17
Q

Unresectable melanoma with V600E mutation in BRAF gene; tx

A

Vemurafenib

18
Q

Radiation; MOA

A

Oxygen free radicals cause damage to cellular DNA

19
Q

Most common bone primary site for Ewing sarcoma and tx

A

Pelvis, radiation

20
Q

Pembrolizumab and nivolumab; MOA

A

Inhibits PD-1

21
Q

Chemotherapy agent causing life-threatening pulmonary fibrosis

A

Bleomycin

22
Q

Most variable phase in cell cycle

A

G1

23
Q

Post-transplant lymphoproliferative disorder associated with what infection

A

EBV

24
Q

Colon and rectal Ca tumor marker

A

CEA

25
Q

HCC tumor marker

A

AFP

26
Q

Pancreatic and biliary tumor marker

A

CA 19-9

27
Q

Prostate tumor marker

A

PSA

28
Q

Ovarian tumor marker

A

CA 125

29
Q

Melanoma, breast, lung, gastric, colorectal tumor marker

A

LDH

30
Q

Gene involved in Li-Fraumeni

A

TP53

31
Q

Protein that plays a role in regulation through cell cycle, apoptosis and genomic stability. Recognizes DNA damage

A

p53

ABSITE (34 decks)

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