Oncology Flashcards
Molecule leading to cachexia by increased catabolism and insulin resistance
TNF
Testing for all newly diagnosed colon cancers
Mismatch repair, Microsatellite instability
Risk factor for hepatic angiosarcoma
Vinyl chloride
Management of carcinoid tumors
Surgical excision
Management of metastatic carcinoid
Surgical debulking, IR embolization, somatostatin analogs (lanreotide), chemo
Medullary thyroid cancer in young patient with family hx; screening
Screen for MEN IIA/IIIB
Colorectal cancer starting on EGFR; tumor marker and treatment
KRAS testing for wild type, cetuximab
Positive PET mediastinum for melanoma; next step
Mediastinal exploration/bx due to 10-20% false positive rate
Most common location somatostatinomas
Head of pancreas
Prognostic factors for GIST
Tumor size and mitotic rate (less than 2cm and <5 low risk)
Alkylating agents (Oxaliplatin and Carboplatin); MOA
Directly damage DNA
Taxol (paclitaxel); MOA
Microtubule stabilization
Irinotecan, doxorubicin, etoposide; MOA
Topoisomerase inhibitors
Chlorambucil, cyclophosphamide, streptozocin; MOA
DNA alkylation
Vincristine, vinblastine; MOA
arrest cell in metaphase, disrupt mitotic spindle
Berberine, ethidium, bromide, proflavine, daunomycin, doxorubicin, thalidomide; MOA
DNA intercalators
Unresectable melanoma with V600E mutation in BRAF gene; tx
Vemurafenib
Radiation; MOA
Oxygen free radicals cause damage to cellular DNA
Most common bone primary site for Ewing sarcoma and tx
Pelvis, radiation
Pembrolizumab and nivolumab; MOA
Inhibits PD-1
Chemotherapy agent causing life-threatening pulmonary fibrosis
Bleomycin
Most variable phase in cell cycle
G1
Post-transplant lymphoproliferative disorder associated with what infection
EBV
Colon and rectal Ca tumor marker
CEA
HCC tumor marker
AFP
Pancreatic and biliary tumor marker
CA 19-9
Prostate tumor marker
PSA
Ovarian tumor marker
CA 125
Melanoma, breast, lung, gastric, colorectal tumor marker
LDH
Gene involved in Li-Fraumeni
TP53
Protein that plays a role in regulation through cell cycle, apoptosis and genomic stability. Recognizes DNA damage
p53
