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ABSITE > Heme/ID > Flashcards

Heme/ID Flashcards

1
Q

IgG antibodies against glycoprotein IIb/IIa and IR/IX; dx

A

Immune thrombocytopenia purpura

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2
Q

Most significant factors influencing oxygen content in the blood

A

Hgb and Hct

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3
Q

Binds to plasminogen and increases plasmin production

A

Streptokinase

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4
Q

binds to glycoprotein Ib on the platelet

A

Von Willebrand factor

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5
Q

Contributes to platelet aggregation and sealing at site of injury

A

Thromboxane A2

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6
Q

Binds platelets to fibrinogen to form platelet plug

A

GPIIb/IIIa

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7
Q

Catalyzes fibrin from fibrinogen stabilizing platelet plug

A

Thrombin

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8
Q

Abciximab, eptifibatide, tirofiban; MOA

A

inhibit GPIIb/IIIa

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9
Q

Most common inherited hypercoaguable disorder; mechanism

A

Factor V Leiden, cannot be activated by protein C

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10
Q

Acute mild transfusion reaction; tx

A

Slow transfusion and observe 30min, can administer antihistamine

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11
Q

First-line treatment surgical bleeding in patient with type I and II vW disease

A

Desmopression

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11
Q

First-line treatment surgical bleeding in patient with type I and II vW disease

A

Desmopression

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12
Q

Warfarin induced skin necrosis; tx

A

stop Warfarin, administer vit K, start systemic heparin

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13
Q

Hx vW disease type 3 s/p trauma with large epidural hematoma; tx

A

factor VIII/vWF concentrate

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14
Q

CHADS-VASc score

A

Congestive heart failure [1 point if present], Hypertension [1 point if present],
Age >75 years [2 points if present],
Diabetes [1 point if present],
Stroke/TIA/Embolism [2 points if present],
Vascular disease,
Age 65 to 74 years [1 point],
Sex category female [1 point]

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15
Q

Non-valvular afi, CHA2DS2-VASc <5 undergoing low risk surgery ie IHR; periop warfarin mgmnt

A

Stop 5 days before

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16
Q

Periop management of DOACs (apixaban)

A

Held 2 days pre-op

17
Q

Periop management warfarin with CHADS-VASc 6 or higher

A

Bridge

18
Q

HIT treatment

A

Stop heparin and switch to argatroban

19
Q

HIT; MOA

A

Heparin-dependent antibody IgG binds to platelets are formed when heparin binds to platelet factor 4 (PF4)

20
Q

HIT in patient with liver failure

A

Switch to Fondaparinux

21
Q

Post-op bleed in hypothermic patient; next step

A

Rewarm

22
Q

Uremic bleeding with renal failure; tx

A

desmopressin (dDAVP) or dialysis

22
Q

Uremic bleeding with renal failure; tx

A

desmopressin (dDAVP) or dialysis

23
Q

Only blood product without risk for viral hepatitis transmission

A

Albumin

24
Q

Consequence of massive transfusion

A

Hypocalcemia -> hypotension decreased pulse pressure, long QT

25
Q

Heparin; MOA, half-life and reversal agent

A

Activates antithrombin III, 1hr, protamine

26
Q

Enoxaparin; MOA, half-life and reversal agent

A

Activates antithrombin III, inhibits factor Xa, 5hrs, protamine

27
Q

Fondaparinux; MOA, half-life and reversal agent

A

Activates antithrombin III, inhibits factor Xa, 17-20hrs, none

28
Q

Dabigatran; MOA, half-life and reversal agent

A

Direct thrombin inhibitor,12-14hrs, Idarucizumab some PCC

29
Q

Argatroban; MOA, half-life and reversal agent

A

Direct thrombin inhibitor, <1hr, PCC

30
Q

Bivalrudin; MOA, half-life and reversal agent

A

Direct thrombin inhinbitor, 20-30min, none

31
Q

Rivaroxaban; MOA, half-life and reversal agent

A

Directly inhibits factor Xa, 5-9hrs, Andexanet alfa, some PCC

32
Q

Apixaban; MOA, half-life and reversal agent

A

Directly inhibits factor Xa, 9-13hrs, Andexanet alfa, some PCC

33
Q

Warfarin; MOA, half-life and reversal agent

A

Vit K antagaonist, PCC, vit K, FFP

34
Q

Hx of Factor XI deficiency, tx preop

A

FFP

35
Q

R time; what, issue and tx

A

Clotting time, no factors, FFP

36
Q

K value; what, issue and tx

A

Clot time to strengthen, Fibrinogen, cryo

37
Q

Alpha angle; what, issue and tx

A

Fibrin accumulation, fibrinogen, cryo

38
Q

MA; what, issue and tx

A

Max clot strength, platelets, platelets or dDAVP

39
Q

LY30; what, issue and tx

A

Lysis, Excess fibrinolysis, TXA

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