Oncology Flashcards
Extravasation
The escape of blood or lymph from their proper vessels into surrounding tissues.
Vesicants
An agent that causes blistering.
Nadir
The point at which blood cell counts are at their lowest after a chemotherapy treatment.
thrombocytopenia
A blood disease characterized by an abnormally low number of platelets in the bloodstream
leukopenia
when the levels of WBCs in your blood are lower than average.
desquamation
The shedding of the outer layers of the skin
intrathecal
- within a sheath. 2. through the theca of the spinal cord into the subarachnoid space.
Uncontrolled cell growth
Cancer
2nd leading cause of death in the U.S.
Cancer
Causes of cancer
some genetic tendencies, some related to environmental expose, some related to infectious agents
Infectious agents that can cause cancer
human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), and Helicobacter pylori (H. pylori),
Cancer can be prevented through
behavioral changes, vaccination, or treatment of the infection.
A process that begins when an abnormal cell is created by the genetic mutation of a cell’s DNA
Cancer pathophysiology
Increased cell growth
proliferation
Cancer cells that don’t always multiply rapidly, but do increase & spread without cell “boundaries”
proliferation
Cells should grow into the mature type- if not they remain like immature or fetal cells…
differentiation
UN-LIKE the mature cell
undifferentiated
Pre-malignant or malignant
differentiation
Number 1 Carcinogen
Tobacco smoke
Environmental Carcinogens:
tobacco, exposure to occupational chemicals, asbestos, benzene
30% of cancer can be traced to
Smoking and 2nd hand smoke
Environmental Carcinogen drugs
pesticides
Environmental Carcinogens viruses
Epstein-Barr, HPV, h. pylori
Environmental Carcinogen: radiation
sun, treatment, radon, nuclear exposure
Potential causes of mutations from diet
eating too many animal proteins/fats, alcohol, and cured foods
Epstein-Barr is linked to
mononucleosis
Potential causes of mutation relating to immune response
Autoimmune disorders and medications
Potential causes of mutations in genetics
chromosome/genes (BRCA1 &2?)
TAA’s (proteins)
Tumor associated antigens on surface of cancer cells
lymphokines& Tumor Necrosis Factors=
CELL DEATH
cytotoxic B lymphocytes & Killer T cells kill cells with
TAA
7 Warning Signs: CAUTION
C hange in bowel/bladder
A sore does not heal
U nusual bleeding
T thickening or lump
I indigestion
O bvious change in wart
N agging cough
Change in bowel/bladder could indicate
Colon, prostate, or bladder cancer
A sore that does not heal could indicate
Leukemia or lymphoma
Unusual bleeding could indicate
Leukemia
Thickening or a lump could indicate
Breast cancer or lymphoma
Indigestion could indicate
Cancer of the GI tract
Obvious change in a wart could indicate
Skin cancer
A nagging cough could indicate
Lung cancer or lymphoma
Baseline breast screening is done at age
35
Breast screening is performed
mammo over 40y annually
Colon screening is performed
starting at age 45: colonoscopy every 10 years
occult blood is tested
yearly
Virtual colonography is performed
Every 5 years
Prostate exam is performed
PSA & digital exam is done annually starting at age 50
PSA
Prostate specific antigen
What is PSA?
PSA is a protein produced by the prostate gland
Pap smear is performed:
Every 3 years when over 21 yrs of age
Americans are too sedentary and their diet is too high in
saturated fats
Prevention education includes the dangers of
smoking and excessive alcohol use
Primary cancer health action
Prevent
Primary cancer promotions
Educate about risks
Diet & lifestyle changes
Cancer prevention programs
Secondary cancer health action
Find early
Secondary cancer health action
Identification of at risk groups
Cancer Screening
Classification of cancer:
from embryonic skin, gland, mucous membranes of resp. tract, GI & GU
Carcinomas
Known as “solid tumors”
Carcinomas
Classification of cancer:
connective tissue, muscle, bone, fat
Sarcomas
Classification of cancer:
hematopoietic system (bone marrow)
Lymphoma, leukemia, and Hodgkins/Non Hodgkins
Known as “liquid” or “blood” tumors
Lymphoma, leukemia, and Hodgkins/Non Hodgkins
Glandular tumors
adenocarcinomas
Tumors of the bone
Osteosarcoma
Grading and staging of tumors is determined by
A pathologist
pattern of growth in which cells lack normal characteristics and differ in shape and
organization with respect to their cells of origin; usually, anaplastic cells are malignant (Grade IV)
anaplasia
The presence of cells of an abnormal type within a tissue, which may signify a stage
preceding the development of cancer (grades I-III)
dysplasia
Grading by cell appearance:
I
slightly different (dysplagia)
Grading by cell appearance:
II
moderate dysplagia
Grading by cell appearance:
III
very abnormal -poor differentiation
Grading by cell appearance:
IV
Immature, fetal, not same as mature cell (anaplastic)
Grade IV is sometimes difficult to identify
Cell origin
cells or tissues that have lost their mature or specialized features
Anaplastic
How different is the cell?
Well differentiated
Similar
How different is the cell?
Moderately differentiated
Less similar
How different is the cell?
Extremely differentiated
Anaplastic
Stage 0
in situ
In situ
the earliest stage, non-invasive
Stage 1
local- in tissue of origin
Stage 2
limited, local
Stage 3
extensive, regional lymph node or tissue extent
Stage 4
metastasis
Staging:
present, not invading
stage 0
Staging:
In tissue of origin, potential for motion
Stage 1
Staging:
Great potential to spread
Stage 2
Staging:
extensive but no evidence of metastasis
Stage 3
Staging:
Travelled to different area of body
Stage 4
Grading scale used for prostate
Gleason scale
The lymph system can be an indicator of
where the tumor is
Tumor is sometimes washed towards
lymph nodes closest to origin
metastasis
cancer has spread to a different body part than where it started
Common symptoms of brain metastasis
Headaches, seizures, vertigo, vision problems
Common symptoms of respiratory metastasis
Cough, hemoptysis, dyspnea
Common symptoms of lymph node metastasis
lymphadenopathy
Common symptoms of liver metastasis
Hepatomegaly, jaundice
Common symptoms of skeletal metastasis
fractures, pain, spinal cord compression
CEA
carcinoembryonic antigen (associated with bowel cancer)
CA125
ovarian cancer indicator
Immature Cells
blast or stem cells
cells that look like “fetal” or immature cells can be found
in the blood with certain cancers
Diagnostic labs
CBC, WBC
diagnostic tests
Biopsy-
MRI
CAT
Endoscopy
Xray
PET scans
the 3 goals
CURE
CONTROL
PALLIATION
the 4 treatments
SURGERY
RADIATION
CHEMOTHERAPY
BIOLOGIC AGENTS
Types of cancer surgery
debulk, radical, supportive
Types of radiation
internal or external
Curative surgery
Completely removes all cancer/tumor
Type of surgery such as colostomy for obstruction, insert drainage tubes, PEG’s etc
Supportive (palliative)
Surgery for prevention
Prophylactic
If there is numbness, there may be ______ of the spine
compression
Lung and breast cancer can be found in the
brain
abnormal size or consistency of the lymph nodes
lymphadenopathy
Colon cancer will first travel to
Liver
Prostate and breast cancer will travel to
the bones
TNM
Tumor, Node, Metastasis
TNM Classification:
T
Tumor size
TNM Classification:
N
Lymph nodes involved
TNM Classification:
M
metastasis