Long term Complications of Diabetes Flashcards
Long term complications of diabetes usually does not occur until
10 years after diagnosis
Hyperglycemia causes changes to
the medium layer of large vessels
Blood vessels thicken and
sclerosis plaque adheres to walls
This accelerated atherosclerosis causes
diminished blood flow
These atherosclerosis changes happen more often in
diabetics and at earlier age
Diabetics have twice the risk of disease and death than
non-diabetics
Recovery from stroke can be impaired in
Cerebrovascular Disease causing neuropathy
S&S of Cerebrovascular Disease can
mimic
hypoglycemia and looks like a stroke
The typical S&S of Coronary Artery Disease
may
not be present = silent MI’s
Blockage or narrowing of an artery in the legs (or rarely the arms), usually due to atherosclerosis and resulting in decreased blood flow.
Occlusive peripheral arterial disease
Causes a greater incidence of gangrene, amputation in diabetics
Peripheral Vascular Disease
Management of macrovascular complications
Aggressive modification of risk factors such as smoking, hypertension, diet, exercise
Microvascular complications
Increased blood glucose causes thickening of capillary basement membrane
Microvascular complications affect
Eyes
Kidneys
Nerves
Almost all patients with type 1 diabetes and majority of pts with type 2 have some degree of
retinopathy after 20 years.
Small vessels in the retina are affected in
diabetic retinopathy
Three phases of diabetic retinopathy:
non-proliferative, pre-proliferative, and pro-liferative
Phases of diabetic retinopathy:
Early stage. Asymptomatic. Micro aneurysms, fluid leak
Non-proliferative
Macular edema (10% of pt’s) can lead to
visual changes and loss of central vision
Edema around the retina
Macular edema
Phases of diabetic retinopathy:
Increased destruction of retinal blood vessels
Possible vision changes from macular edema
Pre-proliferative
Phases of diabetic retinopathy:
Abnormal growth of new blood vessels growing from retina into the vitreous
New vessels rupture, vitreous becomes cloudy block light – loss of vision
Scar tissue forms in vitreous – pulls retina, retina detachment
Proliferative
vitreous means
becomes cloudy
Is retinopathy painful?
No
Diabetic retinopathy is the ___ leading cause of blindness
3rd
Early stages of diabetic retinopathy
lesions and macular edema causes blurry vision
Later stages of diabetic retinopathy
Hemorrhage S&S: floaters, cobwebs, sudden hazy vision, could lead to compete vision loss
Diagnostic Tests for diabetic retinopathy:
Ophthalmoscopic exam of
dilated pupils to exam retina
Diagnostic Tests for diabetic retinopathy:
Rare exam where dye is injected into arm vein travels to vessels of retina
Fluorescein angiography
Management of diabetic retinopathy
Prevention
Keep blood glucose at near normal levels
Yearly eye exams
Control HTN, smoking cessation
Advanced cases – Photocoagulation
Major hemorrhage: vitrectomy