Oncogenic viruses Flashcards
1
Q
E2
A
HPV gene
dampens expression of E6 and E7
2
Q
E6
A
HPV gene
p53 degradation
3
Q
E7
A
HPV gene
inactivates Rb
4
Q
HPV permissive cells
A
virus infects cells and leads to a lytic cycle
5
Q
HPV nonpermissive cells
A
does not lead to productive infection of the virus
can its make genome but missing something needed for structural proteins for infection
low risk: warts
high risk: cancer
6
Q
Tax gene
A
leads to degradation of IkB by phosphorylation
7
Q
Cip
A
CdK inhibitor
8
Q
Ink4
A
CdK inhibitor
9
Q
KSHV
A
produces v-cyclin that constitutively activates CdK6 by making it immune to Cip or Ink4
10
Q
LMP-1
A
EBV transmembrane protein
activates kinase cascade that localizes NF-kB to nucleus in B-cells, leading to immortilization
11
Q
HTLV-1
A
infects and transforms CD4 T cells
