Pathology: Cancer Flashcards
1
Q
p16INK4A mutation
A
tumor suppressor
CDKI: inhibits cyclin D/CDK progression from G1 to S phase
germline mutation present in 25% of melanoma
2
Q
dominant tumor suppressor mutations
A
familial is first hit
somatic second hit
3
Q
recessive tumor suppressor mutations
A
both hits are somatic
4
Q
Tumoral CDKN2A mutation
A
p16
adult glioblastomas
5
Q
Most important somatic CDKN2A mutation
A
pancreatic carcinoma
6
Q
neuroblastoma
A
pediatric tumor of neural crest derived cells
adrenal carcinoma
7
Q
glioblastoma
A
brain tumor in adults
