Oncogenes/tumor suppressor genes Flashcards
1
Q
abl
A
CML tumor,tyrosine kinase
2
Q
c-myc
A
Burkitt’s lymphoma, Transcription factor
3
Q
bcl-2
A
follicular and undifferentiated lymphomas, anti-apoptotic
4
Q
Her2/neu
A
Breast, ovarian, gastric carcinoma, tyrosine kinase
5
Q
ras
A
colon carcinoma, GTPase
6
Q
L-myc
A
lung tumor, transcription factor
7
Q
N-myc
A
neuroblastoma, transcription factor
8
Q
ret
A
MEN types 2A/2b, tyrosine kinase
9
Q
c-kit
A
Gastrointestinal stromal tumor(GIST), cytokine receptor
10
Q
Rb
A
Retinoblastoma, osteosarcoma. Inhibits E2F; blocks G1 -> S phase
11
Q
p53
A
Most cancers, Li-Fraumeni syndrome. Transcription factor for p21, blocks G->S
12
Q
BRCA1
A
Breast and ovary cancer. DNA repair
13
Q
BRCA2
A
Breast and ovary cancer. DNA repair
14
Q
p16
A
Melanoma
15
Q
BRAF
A
Melanoma
