Oncogenes/tumor suppressor genes

Question 1

abl

Answer 1

CML tumor,tyrosine kinase

Question 2

c-myc

Answer 2

Burkitt’s lymphoma, Transcription factor

Question 3

bcl-2

Answer 3

follicular and undifferentiated lymphomas, anti-apoptotic

Question 4

Her2/neu

Answer 4

Breast, ovarian, gastric carcinoma, tyrosine kinase

Question 5

ras

Answer 5

colon carcinoma, GTPase

Question 6

L-myc

Answer 6

lung tumor, transcription factor

Question 7

N-myc

Answer 7

neuroblastoma, transcription factor

Question 8

ret

Answer 8

MEN types 2A/2b, tyrosine kinase

Question 9

c-kit

Answer 9

Gastrointestinal stromal tumor(GIST), cytokine receptor

Question 10

Rb

Answer 10

Retinoblastoma, osteosarcoma. Inhibits E2F; blocks G1 -> S phase

Question 11

p53

Answer 11

Most cancers, Li-Fraumeni syndrome. Transcription factor for p21, blocks G->S

Question 12

BRCA1

Answer 12

Breast and ovary cancer. DNA repair

Question 13

BRCA2

Answer 13

Breast and ovary cancer. DNA repair

Question 14

p16

Answer 14

Melanoma

Question 15

BRAF

Answer 15

Melanoma

Question 16

APC

Answer 16

Colorectal cancer

Question 17

WT1

Answer 17

Wilm’s Tumor

Question 18

NF1

Answer 18

neurofibromatosis type 1. RAS GTPase activating protein

Question 19

NF2

Answer 19

Neurofibromatosis type 2. Merlin (schwannomin) protein

Question 20

DPC4

Answer 20

pancreatic cancer. Deleted in pancreatic cancer

Question 21

DCC

Answer 21

Colon cancer. Deleted in colon cancer.