Immunodefeciences Flashcards

1
Q

IL-1

A

Fever, acute inflammation, activates endothelium.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

IL-2

A

Stimulate growth of helper, cytotoxic and regulator T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

IL-3

A

supports growth and differentiation of bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

IL-4

A

Induces differentiation into Th2, Class switching to IgG and IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

IL-5

A

Promotes differentiation of B cells. Switching to IgA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

IL-6

A

Fever, stimulates acute-phase proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

IL-8

A

Chemotactic for neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

IL-10

A

Inhibits actions of activated T cells and Th1. Similar to TGFb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

IL-12

A

T cells into Th1 cells. Activates NK

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

TNFa

A

Activates endothelium, leukocyte recruitment, vascular permeability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

INFy

A

Activates macrophages and TH1 cells. Suppression of Th2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CD3

A

T cell TCR signal transduction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CD28

A

T cell binds to B7 on APC. costimulatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

CD19, CD20, CD21

A

B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

CD16, CD56

A

Natural Killer cells. CD56 unique

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Serum Sickness

A

Type III immune complex. Antibodies to foreign protein after 5 days. Complexes fix complement and damage tissue/

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

X-linked Brutons agammaglobulinemia

A

X linked recessive defect in BTK tyrosine kinase preventing B cell maturation. Increased bacterial infection. Normal B cells, decreased maturation, decrease Ig

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Selective IgA deficiency

A

Anaphaylaxis to IgA containing blood products. IgA <7 mg/dl with normal IgG, IgM and IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Common variable immunodeficiency

A

Defect in B-cell maturation, acquired in 20-30s, increased risk of autoimmune diseases. normal B cells, decreased plasma cells

20
Q

Thymic aplasia DiGeorge syndrome

A

22q11 failure to develop 3/4 pouches. Tetany(hypocalcemia) increased viral/fungal infections and congenital heart/vessel defects. Absent thymic shadow

21
Q

IL-12 receptor deficiency

A

Decreased Th1 response. Mycobacterial infections

22
Q

Hyper IgE jobs syndrome

A

Th1 doesnt produce IFNy and neutrophils thus dont respond to chemotactic stimuli.

FATED: coarse Facies, cold staph Absecess, primary Teeth, IgE increased, Derm problems

23
Q

Chronic candidiasis

A

T cell dysfunction

24
Q

SCID

A

X-linked defective IL-2 receptor or adenosine deaminase deficiency. Absence of T and B cells and thymic shadow

25
Q

Ataxia Telangiectasia

A

Defect in ATM DNA repair gene. Increased AFP. Ataxia, telangiectasia and IgA defiecency

26
Q

Hyper IgM syndrome

A

Defective CD40L on helper T cell. Cant class switch IgM increased others decreased

27
Q

Wiskott Aldrich syndrome

A

X-linked, T cells cant reorganize actin cytoskeleton.

TIE: thrombocytopenic purpura, infections, Eczema

Increased IgE, IgA
Decreased IgM

28
Q

Aldesleukin

A

IL-2. renal cell carcinoma, metastatic melanoma

29
Q

Epoetin alfa

A

anemia

30
Q

filgrastim

A

recovery of BM

31
Q

sargramostim

A

recovery of BM

32
Q

a-interferon

A

B and C hepatitis, Kaposi’s sarcoma, leukemia, malignant melanoma

33
Q

B-interferon

A

Multiple sclerosis

34
Q

Y-interferon

A

Chronic granulomatous disease

35
Q

Oprelvekin

A

IL-11. Thrombocytopenia

36
Q

Thrombopoietin

A

Thrombocytopenia

37
Q

Muromonab OKT3

A

CD3, acute transplant rejection

38
Q

Digoxin immune Fab

A

Digoxin intoxication

39
Q

Infliximab

A

TNF-a, chrons disease, Rheumatoid arthritis, psoriatic arthritis.

40
Q

adalimumab

A

TNF-a, chrons disease, Rheumatoid arthritis, psoriatic arthritis.

41
Q

Abciximab

A

Glycoprotein IIb/IIIA. prevent cardiac ischemia in angina

42
Q

Trastuzumab(herceptin)

A

Her2 in breast cancer

43
Q

Rituximab

A

CD20. B cell non hodgkins lymphoma

44
Q

Omalizumab

A

IgE. Asthma

45
Q

Leukocyte adhesion deficiency type 1

A

Defect in LFA-1 integrin on phagocytes. Recurrent bacterial infections, absent pus formation, delayed separation of umbilical cord.

Neutrophilia

46
Q

Chediak-Higashi syndrome

A

Autosomal recessive defec in lysosomal trafficking regulator gene. Microtubule dysfunction in phagosome-lysosome fusion.

Recurrent pyogenic infections by staph and strep; partial albinism, peripheral neuropathy

47
Q

Chronic granulomatous disease

A

Lack of NADPH oxidase leading to decrease of reactive oxygen species. Absent respiratory burst in the neutrophils. Increased susceptibility to catalase positive organisms.