Immunodefeciences Flashcards
IL-1
Fever, acute inflammation, activates endothelium.
IL-2
Stimulate growth of helper, cytotoxic and regulator T cells
IL-3
supports growth and differentiation of bone marrow
IL-4
Induces differentiation into Th2, Class switching to IgG and IgE
IL-5
Promotes differentiation of B cells. Switching to IgA
IL-6
Fever, stimulates acute-phase proteins
IL-8
Chemotactic for neutrophils
IL-10
Inhibits actions of activated T cells and Th1. Similar to TGFb
IL-12
T cells into Th1 cells. Activates NK
TNFa
Activates endothelium, leukocyte recruitment, vascular permeability
INFy
Activates macrophages and TH1 cells. Suppression of Th2
CD3
T cell TCR signal transduction
CD28
T cell binds to B7 on APC. costimulatory
CD19, CD20, CD21
B cells
CD16, CD56
Natural Killer cells. CD56 unique
Serum Sickness
Type III immune complex. Antibodies to foreign protein after 5 days. Complexes fix complement and damage tissue/
X-linked Brutons agammaglobulinemia
X linked recessive defect in BTK tyrosine kinase preventing B cell maturation. Increased bacterial infection. Normal B cells, decreased maturation, decrease Ig
Selective IgA deficiency
Anaphaylaxis to IgA containing blood products. IgA <7 mg/dl with normal IgG, IgM and IgG