Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Path > Immunodefeciences > Flashcards

Immunodefeciences Flashcards

1
Q

IL-1

A

Fever, acute inflammation, activates endothelium.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

IL-2

A

Stimulate growth of helper, cytotoxic and regulator T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

IL-3

A

supports growth and differentiation of bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

IL-4

A

Induces differentiation into Th2, Class switching to IgG and IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

IL-5

A

Promotes differentiation of B cells. Switching to IgA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

IL-6

A

Fever, stimulates acute-phase proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

IL-8

A

Chemotactic for neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

IL-10

A

Inhibits actions of activated T cells and Th1. Similar to TGFb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

IL-12

A

T cells into Th1 cells. Activates NK

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

TNFa

A

Activates endothelium, leukocyte recruitment, vascular permeability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

INFy

A

Activates macrophages and TH1 cells. Suppression of Th2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CD3

A

T cell TCR signal transduction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CD28

A

T cell binds to B7 on APC. costimulatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

CD19, CD20, CD21

A

B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

CD16, CD56

A

Natural Killer cells. CD56 unique

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Serum Sickness

A

Type III immune complex. Antibodies to foreign protein after 5 days. Complexes fix complement and damage tissue/

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

X-linked Brutons agammaglobulinemia

A

X linked recessive defect in BTK tyrosine kinase preventing B cell maturation. Increased bacterial infection. Normal B cells, decreased maturation, decrease Ig

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Selective IgA deficiency

A

Anaphaylaxis to IgA containing blood products. IgA <7 mg/dl with normal IgG, IgM and IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Common variable immunodeficiency

A

Defect in B-cell maturation, acquired in 20-30s, increased risk of autoimmune diseases. normal B cells, decreased plasma cells

20
Q

Thymic aplasia DiGeorge syndrome

A

22q11 failure to develop 3/4 pouches. Tetany(hypocalcemia) increased viral/fungal infections and congenital heart/vessel defects. Absent thymic shadow

21
Q

IL-12 receptor deficiency

A

Decreased Th1 response. Mycobacterial infections

22
Q

Hyper IgE jobs syndrome

A

Th1 doesnt produce IFNy and neutrophils thus dont respond to chemotactic stimuli.

FATED: coarse Facies, cold staph Absecess, primary Teeth, IgE increased, Derm problems

23
Q

Chronic candidiasis

A

T cell dysfunction

24
Q

SCID

A

X-linked defective IL-2 receptor or adenosine deaminase deficiency. Absence of T and B cells and thymic shadow

25
Q

Ataxia Telangiectasia

A

Defect in ATM DNA repair gene. Increased AFP. Ataxia, telangiectasia and IgA defiecency

26
Q

Hyper IgM syndrome

A

Defective CD40L on helper T cell. Cant class switch IgM increased others decreased

27
Q

Wiskott Aldrich syndrome

A

X-linked, T cells cant reorganize actin cytoskeleton.

TIE: thrombocytopenic purpura, infections, Eczema

Increased IgE, IgA
Decreased IgM

28
Q

Aldesleukin

A

IL-2. renal cell carcinoma, metastatic melanoma

29
Q

Epoetin alfa

A

anemia

30
Q

filgrastim

A

recovery of BM

31
Q

sargramostim

A

recovery of BM

32
Q

a-interferon

A

B and C hepatitis, Kaposi’s sarcoma, leukemia, malignant melanoma

33
Q

B-interferon

A

Multiple sclerosis

34
Q

Y-interferon

A

Chronic granulomatous disease

35
Q

Oprelvekin

A

IL-11. Thrombocytopenia

36
Q

Thrombopoietin

A

Thrombocytopenia

37
Q

Muromonab OKT3

A

CD3, acute transplant rejection

38
Q

Digoxin immune Fab

A

Digoxin intoxication

39
Q

Infliximab

A

TNF-a, chrons disease, Rheumatoid arthritis, psoriatic arthritis.

40
Q

adalimumab

A

TNF-a, chrons disease, Rheumatoid arthritis, psoriatic arthritis.

41
Q

Abciximab

A

Glycoprotein IIb/IIIA. prevent cardiac ischemia in angina

42
Q

Trastuzumab(herceptin)

A

Her2 in breast cancer

43
Q

Rituximab

A

CD20. B cell non hodgkins lymphoma

44
Q

Omalizumab

A

IgE. Asthma

45
Q

Leukocyte adhesion deficiency type 1

A

Defect in LFA-1 integrin on phagocytes. Recurrent bacterial infections, absent pus formation, delayed separation of umbilical cord.

Neutrophilia

46
Q

Chediak-Higashi syndrome

A

Autosomal recessive defec in lysosomal trafficking regulator gene. Microtubule dysfunction in phagosome-lysosome fusion.

Recurrent pyogenic infections by staph and strep; partial albinism, peripheral neuropathy

47
Q

Chronic granulomatous disease

A

Lack of NADPH oxidase leading to decrease of reactive oxygen species. Absent respiratory burst in the neutrophils. Increased susceptibility to catalase positive organisms.

Path (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions