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Onc Flashcards

1
Q

Ph Chromosome =

A

CML

also Bcr-Abl mutation

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2
Q

Which med treats CML?

A

Gleevec

Decreases risk for crisis de la blasts

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3
Q

African americans and pacific islanders are at higher risk for which blood dz?

A

MM

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4
Q

Monoclonal protein, roleaux formation =

A

MM

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5
Q

Most common adult leukemia?

A

CLL

affects B lymphocytes

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6
Q

smudge cells =

A

CLL

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7
Q

Which blood dz is hydroxyurea and asa used to tx?

A

PV

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8
Q

Cisplatin causes?

A

Renal tox

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9
Q

Which med causes ruby red urine?

A

Adriamycin

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10
Q

Which drug treats B-cell NHL

A

Rituximab

Cardiotoxic

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11
Q

Ipilimubab causes?

A

Endocrine failure

No cortisol

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12
Q

Cytoxan (cyclophosphamide) causes?

A

Hemorrhagic cystitis

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13
Q

Vincristine causes?

A

Peripheral Neuropathy

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14
Q

Does DCIS affect one or 2 breasts?

A

Always one

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15
Q

Infiltrating ductal carcinoma

A

Most common type of invasive BCA

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16
Q

Which therapy is used for ER/PR tumors?

A

Tamoxifen

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17
Q

What is used for HER2 BCA?

A

Trastazumab

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18
Q

Doxyrubicin causes?

A

Cardiac complications

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19
Q

Bleomycin causes?

A

Pulmonary fibrosis

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20
Q

What is a SE of tamoxifen

A

blood clots

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21
Q

Which ovarian CA occurs in younger women?

A

Germ Cell

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22
Q

What is the most common ovarian CA in older women?

A

Epithelial

23
Q

Tests for ovarian CA

A

CA-125 and HE4

24
Q

BRCA genes are associated with which cancers?

A

Breast and Ovarian

25
Q

Is radiation used for ovarian CA?

A

No

26
Q

Most common GYN CA in the US?

A

Endometrial

27
Q

Type 1 Adenocarcinoma

A

Estrogen sensitive Endometrial CA
Good prognosis
Most common

28
Q

Progestin

A

If added to hormone replacement therapy, lowers risk of endometrial CA.

29
Q

HNPCC

A

Hereditary non-polyposis Colorectal cancer
Lynch syndrome
Runs in families

30
Q

Squamous cell cervical CA

A

Most common type

31
Q

What causes cervical CA?

A

HPV 16, 18, 45

32
Q

Which blood dz usually causes leukostasis?

A

AML

33
Q

Breast and lung cancer can release which hormone?

A

PTHrP

Hypercalcemia ensues

34
Q

Small cell lung cancer secretes?

A

SIADH

35
Q

Hypotension
JVD
Muffled heart sounds

A

Becks triad of cardiac tamponade

36
Q

A smoker with hyponatremia

A

SIADH from SCLC

37
Q

What kind of bone lesions does breast CA make?

A

Lytic bone lesions

38
Q

Ewing lesions are lytic or blastic?

A

lytic then blastic

39
Q

Benign lesions of skeletal long bones. Knee and shoulder are common. Most common skeletal neoplasms.

A

Osteochondroma

40
Q

What type of bone lesions does prostate CA make?

A

Osteoblastic

41
Q

Most common primary bone tumor?

A

MM

42
Q

Which sites met to bone?

A 
Breast
Prostate
Lung
Kidney
Thyroid
43
Q

Most common bone malignancy in kids

A

Osteosarcoma
Long bones
Males in 2nd decade

44
Q

Lytic lesion of the pelvis or long bones with onion skin and blue cells?

A

Ewing sarcoma

45
Q

Axial skeleton tumors in adults that are slow growing and metastasize to lungs?

A

Chondrosarcoma

Also have stippled calcification

46
Q

AFP detects?

A

Liver and germ cell CA

47
Q

Beta hCG detects?

A

Choriocarcinoma and Testicular CA

48
Q

CA 19.9

A

Pancreatic, bile duct, gall bladder, gastric CA

49
Q

CA 125

A

Ovarian CA

50
Q

CEA

A

Colorectal and Breast CA

51
Q

Calcitonin

A

Medullary thyroid CA

52
Q

Reed sternberg cell =?

A

Hodgkin Lymphoma

53
Q

Sunburst pattern, codman’s triangle

A

Osteosarcoma

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