OM- Oral Viral Infections

Question 1

Viral replication stages

Answer 1

Binding
Entry
Release and nuclear transport
Nuclear entry
Gene expression
DNA replication
Packaging
Egress

Question 2

Principles of lab diagnosis

Answer 2

History and examination
Diagnosis
Viral swab
Blood sample
Complete virology request form
Detection of viral nucleic acid
Serology

Question 3

Herpes simplex clinical features

Answer 3

Gingivio stomatitis
Herpes labialis

Question 4

Herpes simplex tx

Answer 4

Aciclovir cream 5%

Question 5

Varicella zoster features

Answer 5

Chickenpox- varicella
Shingles- zoster
Complication- Pneumonia, post herpetic neuralgia

Question 6

Varicella and zoster tx

Answer 6

Chickenpox vaccine
Shingles- aciclovir 800mg 5xdaily for 7D

Question 7

What kind of drug is aciclovir

Answer 7

Antiviral- acyclic purine nucleoside

Question 8

How does aciclovir work

Answer 8

Viral enzymes add a phosphate group to aciclovir
Human enzymes add 2 more phosphate groups, producing aciclovir triphoshate
During viral DNA replication, aciclovir added to growing strand rather than GTP, stopping process