Oestoarthritis

Question 1

What is OA?

Answer 1

Cartilage loss and inflammation of joints

• causes the bones to rub against bone = pain
• associated with ageing, wear and tear, old injuries

Question 2

Components of the synovial joints

• Aggrecan
• Hyaluronan (HA)

And what happens when we age

Answer 2

-acts as a sponge in the cartilage, allows for weight
bearing activity, as it compresses water is squeezed out
also contains chrondratin sulfate and keratin sulfate
-backbone for Aggrecan

• aggrecan gets shorter - less water absorbing ability
• change in matrix turnover: cartilage softens, cracks and falls away

Question 3

Fish oil

Answer 3

There isnt much evidence at all the support this

-it is meant to promote EPA thus less AA and less inflammatory response

Question 4

Glucosamine

Answer 4

this makes up the hyaluronan (component in cartilage)
in theroy prevents the degrdation of cartilage
DO NOT give with shellfish allergy

Question 5

Chrondroitin

Answer 5

Makes up aggrecan (component in cartilage), made from shark cartilage

Question 6

What is the difference between Ibuprofen and Naproxen?

Answer 6

Ibuprofen 
- lasts about 2 hrs
-metabolised by liver first, then excreted 
Naproxen 
-lasts about 15hrs 
excreted by kidney

Question 7

Interactions with NSAIDs

Answer 7

Triply whammp - Nsaid, Diuretic, ace

Avoid in HF - becuase it can cause fluid retention, thus increase Blood pressure
-gastric ulcers - avoid if there is a history here
-renal impairment - increase conc
pregnancy - delays labour
-increase risk of bleeding

Question 8

Intra articular corticosteriods

Answer 8

1. Induces Annexin-1
   - stoping PG,
2. Stops neutrophils
3. increasing healing and repair

Knee only

Question 9

IA hyaluronic acid

Answer 9

1. oiling the joint - libricant

2. Prevents MAP kinases from degading chondrocytes

Question 10

what is aggrecan made of ?

Answer 10

Chrondrotin sulfate and keratin sulfate and proteins all atttached to a hyaluranan central backbone