IBD

Question 1

Difference between Cohn’s and Ulcerative?

Answer 1

Cohn’s = segmented inflammation of deep tissue layer from mouth to anus
-abdominal pain, diarrhoea, malnutritionm, haemorrhoids

Ulcerative = inflammation of superfical tissue on one area, generally on colon/rectum
-bloody stools, weight loss, fatigue, low haemoglobin (bleeding)

Question 2

What are some risk factors for IBD?

Answer 2

Oxidative stress, genetics, sleep disturbances, smoke, bade microbiome, opioids make it worse

Question 3

Sulfazalazine

MOA

Answer 3

5-ASA (aminosalicylate-derivative)

• converted by but bacteria in mezalazine
• has a local effect on GI tract
• metabolised by NAT-1 into something that can cause
• decrease PG synthesis
• decrease chemotaxis
• decrease leukotriene sythnesis

Question 4

Mesalazine

Answer 4

5-ASA (aminosalicylate-derivative)

• has a local effect on GI tract
• metabolised by NAT-1 into something that can cause
• decrease PG synthesis
• decrease chemotaxis
• decrease leukotriene sythnesis

Question 5

Azathiopurine

MOA

Answer 5

Purine antimetabolite

• prodrug of mercaptopurine
• binds to HGRPT
• prevents recycling/production of purines