Antibiotics 1

Question 1

How dose penicillin work?

Answer 1

1. inhibits transpeptidase - stops cross linking of NAM and NAG in bacteria cell wall
2. activation of autolysins which causes destruction of cell wall

Question 2

Benzylpenicillin (PcG)

• spec
• indication

Answer 2

Broad (gram Pos)

• IV only
• Meningitis, CAP, Syphilis

Question 3

Procaine Penicillin

-indication

Answer 3

Pretty much the same as PcG

• IM
• used for Syphilis

Question 4

Benzathine Penicillin

-indication

Answer 4

IM

-rheumatic fever

Question 5

Phenoxymethylpenicillin

-indication

Answer 5

ORAL

-pharyngitis/ strep throat

Question 6

Dicloxacillin

• indication
• special notes
• spec

Answer 6

Good against Staph aureus and Staph pyogenes
-bacteria found on the skin therefore used in skin infections

-Narrow spectrum with antistaphylococcal activity

-With food
(D = Dog food)

Question 7

Flucloxacillin
-indication
spec

Answer 7

Good against Staph aureus and Staph pyogenes
-bacteria found on the skin therefore used in skin infections

-Narrow spectrum with antistaphylococcal activity

Question 8

Amoxicillin

• Spec
• indications
• food?

Answer 8

• moderate spec
• CAP
• doesnt matter with or without food

Question 9

Amoxicillin with Clavulanic acid

• Spec
• indication
• what dose the acid do?

Answer 9

Broad (pos/neg)
-CAP, UTI, sinusitis ect

• With food
• Beta-lactamase inhibitor - acts as suicide molecule

Question 10

Piperacillin with tazobactrum

-Indication

Answer 10

• Pseudomonas aureus -nothing else works

- IV only

Question 11

Ticarcillin with clavulanic acid

-indication

Answer 11

-Pseudomonas aureus- nothing else works