Oesophagus and Stomach 1 and 2 - Oesophageal and Gastric Tumours, Oesophageal Conditions

Question 1

What are the 2 possible types of oesophageal cancer?What is the most common?Where is each more likely to occur?what are the main things that increase the incidence of each type?

Answer 1

Adenocarcinoma (distal oesophagus) - more common - GORDSquamous cell carcinoma (proximal oesophagus) - smoking and drinking

Question 2

signs and symptoms of oesophageal cancer? (8)

Answer 2

dysphagia:where the patient feels food sticking isn’t necessarily where the tumour isodynophagiaupper GI haemorrhageanaemiaweight lossretrosternal painif upper tumour, cough and hoarseness

Question 3

What should be performed if you suspect oesophageal cancer? e.g. presence of dysphagia

Answer 3

An urgent upper GI endoscopyAlso perform a colonoscopy if the patent presents with anaemia

Question 4

What 3 things should be done to help choose treatment for oesophageal and gastric cancers?

Answer 4

Determine treatment intentAssess patient fitnessAccurate staging

Question 5

What is performed to accurately stage an oesophageal cancer?

Answer 5

CT thorax/ abdomen - if normal perform tests belowCT/PET, EUS, Laparoscopy (can spread intra-abdominally causing little seedlings in the abdomen - laparoscopy searches for this)search hard for metastatic diseaseif metastases present = palliative care

Question 6

Palliative treatment options for oesophageal cancer? (3)

Answer 6

ChemotherapyRadiotherapyStenting - not very pleasant to swallow with

Question 7

Treatment options for oesophageal cancer that can be potentially cured?

Answer 7

Surgery with or without NAC - offers better cure rates for early diseaseRadical chemoradiotherapy - complications are more manageable

Question 8

What are the adverse prognostic factors for oesophageal cancer? (3)

Answer 8

Oesophageal obstructionTumour longer than 5cmMetastatic disease

Question 9

Staging of oesophageal cancer using TNM?

Answer 9

Tis = carcinoma in situT1 = invading lamina propria/ submucosaT2 = invading muscularis propriaT3 = Invading adventitiaT4 = invasion of adjacent structuresNx = nodes cannot be assessedNO = no node spreadN1 = regional node metastasise M0 = no distant spreadM1 = distant metastasis

Question 10

What types of gastric cancers do you get? (5)What is the most common type?

Answer 10

Adenocarcinoma - commonest typeRarer:lymphoma - better prognosisGastrointestinal Stomal Tumours - rarely metastasise = better prognosisSquamous cell carcinoma Neuroendocrine tumours

Question 11

Signs and symptoms of gastric cancer? (10)

Answer 11

DysepsiaUpper GI bleedingAnaemiaweight lossAbdominal massAnorexia/ early satietyvomitingHepatomegalyjaundiceascites

Question 12

How do you accurately stage a gastric cancer?

Answer 12

CT thorax/ abdomenLaparoscopy/ EUS

Question 13

Palliative treatment for gastric cancer? (3)

Answer 13

ChemotherapyRadiotherapySurgical palliation e.g. for obstruction(Trastuzamab for Her-2 positive tumours)

Question 14

Treatment for potentially curable gastric cancer?

Answer 14

surgery with or without NACsurgery based treatment is the only potentially curative option radiotherapy is not a treatment option for gastric cancers as the stomach is too big an organ and therefore you would poison the patient with radiotherapy

Question 15

Adverse prognostic factors for gastric cancer (6)?

Answer 15

metastatic diseaseshort historyadvanced ageproximal lesions locally advanced lesionsuperficial gross appearance (limits plastica)

Question 16

What is gastro-oesophageal reflux disease?

Answer 16

Reflux of stomach contents which causes troublesome symptoms and/or complications

Question 17

What causes GORD? (3)

Answer 17

Lower oesophageal sphincter doesnt work properlyIncrease in intra-abdominal pressureGastric acid hyper secretion

Question 18

What type of people have a higher chance of getting GORD? (4)

Answer 18

Pregnant peopleObese peopleSmokersIncreased association with alcohol

Question 19

Symptoms of GORD?

Answer 19

Heartburn (burning retrosternal discomfort after meals, lying, stooping or straining)belchingacid brash (acid/ bile regurgitation)Waterbrash (increased salivation)odynophagia (pain on swallowing e.g. from oesophagitis)nocturnal asthmachronic coughlaryngitissinusitis

Question 20

Complications of GORD?

Answer 20

OesophagitisUlcerationBenign strictureIron-deficiencyBarrett’s oesophagus = increased chance of oesophageal cancer

Question 21

What type of classification is used to classify GORD?

Answer 21

Los Angeles Classification

Question 22

Loss Angeles Classification?

Answer 22

“mucosal break” = a well-demarcated area of slough/ erythema) - used to encompass the old terms ulceration and erosion1 = more than or equal to 1 mucosal break, 5mm long but not extending beyond 2 mucosal fold tops3 = mucosal break continuous between the tops of 2 or more mucosal folds but which involves less than 75% of the oesophageal circumference4 = mucosal break involving greater than or equal to 75% of the oesophageal circumference

Question 23

Treatments fo GORD?

Answer 23

Physically repair the defective valve (surgery)H2 receptor antagonistsPPIsAnti-acids

Question 24

What causes achalasia?

Answer 24

Lower oesophageal sphincter fails to relx

Question 25

Symptoms of achalasia? (4)

Answer 25

DysphagiaregurgitationSubsternal crampsWeight loss

Question 26

Diagnosis of achalasia?

Answer 26

CXR (fluid level in dilated oesophagus)Barium swallow (dilated tapering oesophagus

Question 27

Treatment of achalasia?

Answer 27

endoscopic balloon dilation Heller’s Cardiomyotomythen PPRI Botulinum toxin injections (non-invasive - required every few months) calcium channel blockers and nitrates also relax the sphincter long standing achalasia may cause oesophageal cancer