IBD 2 - Pathology Flashcards
Where is Crohn’s disease most commonly found?
Terminal ileum and colon
Does Crohn’s disease occur in children?More common in males or females?
Yes - occurs in young patients (50% are 20-30 with 90% being 10-40)Males
What is the clinical course of Crohn’s disease?
Chronic Exacerbation and remissionsUnpredictable response to therapySubgroup of patients who go into lasting remission within 3 years of diagnosis
How are patients with Crohn’s disease diagnosed pathologically?
Endoscopy and mucosal biopsy
What type of -omas form in Crohn’s disease?
Granulomas
What causes chronic active inflammation with crypt branching and granulomas?
Crohn’s disease
Are the granulomas in Crohn’s disease caseating?
No
Why do patients with Crohn’s disease get a bowel obstruction?
Due to stricture formation (or inflammation)
What produces the cobble stoning of mucosa in Crohns disease?
Deep fissures
Can you get pseudo polyps in Crohns disease?
Yes (not common)
Does Crohn’s disease cause transmural or superficial inflammation?
Transmural
What complications of Crohns can occur in the crypts?
CryptitisCrypt abscesses
What are the major complications of Crohn’s disease?
Malabsorption (can be iatrogenic - short bowel syndrome)GallstonesFistulasAnal diseaseIntractable diseaseBowel obstructionPerforationMalignancyAmyloidosisExtra-intestinal manifestationsRarely toxic megacolon
What are signs of malabsorption?
Vitamin deficiencyAnemiaHypoproteinemia
What is the name for a fistula between the colon and small intestine?
Enterocolic fistula
What is blind loop syndrome?
n blind loop syndrome a portion of the small intestine becomes bypassed and thus cut off from the normal flow of food. This may lead to malabsorption and small intestinal bacterial overgrowth syndrome (SIBO). It may also be associated with short bowel syndrome.