Nutrient Digestion (Fats, Vitamins and Minerals) Flashcards

1
Q

Almost all ingested fat is a form of

A

Triacylglycerol

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2
Q

All fat digestion takes place in ___ by ___ enzyme

A

The small intestine

Pancreatic lipase

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3
Q

Triacylglycerols

A

Large droplets of lipid

Insoluble in water

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4
Q

Lipase

A

Water soluble enzyme

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5
Q

Lipase mechanism

A

Turns triacylglycerol into a monoglyceride and 2 fatty acids

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6
Q

Where on the droplet can digestion take place

A

Surface (very slow for a large droplet)

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7
Q

Emulsification

A

Divide large lipid droplets into smaller droplets which gives an increased surface area and accessibility to lipase action

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8
Q

Emulsification requires

A
Mechanical disruption of droplets (by smooth muscle contraction which grinds and mixes lumenal contents)
Emulsifying agent (prevents the smaller droplets reforming into larger droplets
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9
Q

Function of amphiphatic molecules

A

Coat droplets to keep them separate

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10
Q

Micelles

A

Similar to emulsion droplets but much smaller

Bile salt + monoglyceride + fatty acids + phospholipids

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11
Q

Micelle breakdown

A

Release of small amounts of free fatty acids and monoglycerides into solution which then diffuse across the plasma membrane of absorbing cells

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12
Q

Dynamic equilibrium of ____ and ____ in solution and in micelles

A

Fatty acids and monoglycerides

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13
Q

After entering epithelial cells, ____ and ____ enter ____ where they are reformed into ____ (by enzymes located within the sER)

A

Fatty acids
Monoglycerides
Smooth endoplasmic reticulum (sER)
Triacylglycerols

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14
Q

Chylomicrons

A

Extracellular fat droplets

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15
Q

Fat soluble vitamins

A

A, D, E, K

Follow same absorptive path as fat

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16
Q

Water soluble vitamins

A

B group, C and folic acid

Either absorbed by passive diffusion or carrier mediated transport

17
Q

Vitamin B12

A

Large charged molecule

Binds to intrinsic factor in stomach to form complex which is absorbed via specific transport mechanism in distal ileum

18
Q

Vitamin B12 deficiency

A

Pernicious anaemia (failure of red blood cell maturation)

19
Q

Iron transported across brush border membrane into ____

A

Duodenal enterocytes via DMT1

20
Q

Iron ions incorporated into

A

Ferritin

21
Q

Unbound iron transported across ____ membrane to ____

A

Serosal

Blood

22
Q

Iron in blood binds to ____

A

Transferrin

23
Q

Ferritin expression regulated depending on body’s iron status
Hyperaemia  increased ferritin levels  more iron bound in enterocytes
Anaemia  decreased ferritin levels  more iron released to blood

A

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