Gastric Secretion Flashcards

1
Q

Functional anatomy of stomach

A

Fundus
Body
Antrum

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2
Q

Fundus

A

Storage

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3
Q

Body

A
Storage
Mucus
HCl
Pepsinogen
Intrinsic factor
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4
Q

Antrum

A

Mixing/grinding

Gastrin

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5
Q

Cellular composition of gastric glands

A

Mucous neck cells
Chief cells
Parietal cells

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6
Q

Mucous neck cells

A

Produce mucus

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7
Q

Chief cells

A

Pepsinogens

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8
Q

Parietal cells

A
HCl
Intrinsic factor (essential)
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9
Q

Mechanisms

A

Make posters

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10
Q

Gastric acid secretion mechanisms

A

Neurocrine
Endocrine
Paracrine

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11
Q

Neurocrine

A

Vagus/local reflexes

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12
Q

Endocrine

A

Gastrin

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13
Q

Paracrine

A

Histamine

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14
Q

Enterogastrones

A

Hormones released from gland cells in duodenal mucosa - secretin, cholecystokinin (CCK), GIP

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15
Q

When are enterogastrones released?

A

In response to acid, hypertonic solutions, fatty acids or monoglycerides in duodenum
Act collectively to prevent further acid build up in duodenum

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16
Q

Strategies of enterogastrones

A

Inhibit gastric acid secretion

Reduce gastric emptying (inhibit motility/contract pyloric sphincter)

17
Q

Inactive precursor of pepsinogen

A

Zymogen

18
Q

Purpose of zymogen storage

A

Prevents cellular digestion

19
Q

When are pepsins inactivated

A

At neutral pH

20
Q

Gastric mucus produced by

A

Surface epithelial cells and mucous neck cells

21
Q

Purpose of gastric mucus

A
Cytoprotective - protects mucosal surface from mechanical injury
Neutral pH (HCO3) => Protects against gastric acid corrosion and pepsin digestion
22
Q

Intrinsic factor

A

Required for vitamin B12 absorption

Intrinsic factor/B12 complex absorbed from ileum

23
Q

Intrinsic factor defect

A

Pernicious anaemia (failure of erythrocyte maturation)