Nuclear Medicine 1 Flashcards
Target organ: liver
In-prostascint
I-131
IV sulfur colloid
Target organ: distal colon
Gallium
Target organ: bladder
MAG 3
MDP
i-123 MIBG
Target organ: renal cortex
DMSA
thallium
Target organ: spleen
In-wbc
Damages rbcs
Octreotide
Target organ: proximal colon
Sestamibi
Oral sulfur colloid
Target organ: gallbladder wall
HIDA
Radionuclide purity
- acceptable
- test
- 0.15 microCi of Mo-99 per 1 milliCi of Tc-99
- dose calibrator with lead shields: Mo-99 is assayed first
Radiochemical purity
Amount of free Tc
95% purity for pertechnetate
92% for sulfur colloid
91% for everything else
-thin layer chromatography
Chemical purity
Amount of aluminum
- 10 micrograms per 1mL
- pH paper
- aluminum contamination shows up as lung activity in a sulfur colloid scan and as liver activity in a Tv scan
Xenon-133
- half life?
- energy?
5.3 days (physical)
80 keV
Gallium-67
- production?
- decay?
- half life?
- energies?
- critical organ?
- cyclotron: bombardment of Zn-68
- half life: 78 hours
- electron capture; emits gamma rays
- Energies: 93 keV, 184 keV, 300 keV, 393 keV
- critical organ: distal colon
I-131
- half life?
- energy?
- 8 days
- 364 keV
thyroid formation in fetus
8-12 week
Breast feeding
- Tc 99m ?
- I -123
- I-131
Tc 99: resume breast feeding in 12-24 hrs
I-123: resume breast feeding in 2-3 days
I-131: stop breastfeeding
when does patient have to be admitted after radioiodine therapy?
- 7mR/h measured at 1 meter from patient’s chest
- 33 mCi of residual activity
Thallium-201
- half life
- production
- decay
- energies
- 73 hours
- cyclotron
- decays by electron caputre
- major emissions are characteristic X rays of daughter product Mercury 201: 69 and 81
dose of morphine for HIDA
0.02-0.04 mg/kg over 30- 60 minutes
dose of CCK for HIDA
0.02 micrograms/kg over 60 minutes
phenobarbital dosing
2.5 mg BID for 5 days (5 mg for 5 days)
cyclotron produced; decay by electron capture
Th-201, Ga-67, In-111, I-123
emission are gamma rays
cyclotron produced, decay by beta plus
C-11, N-13, O-15, F-18
what interval do you perform FDG PET after therapy?
chemo: 2-3 weeks
radiation: 8-12 weeks
SUV calculation
FDG concentration / (dose/body weight)
tumors that are PET cold
- renal cell
- BAC
- anything mucinous
- carcinoid
- bowel implants/peritoneal implants
- prostate
benign things that are PET HOT
- infection/inflamation
- ovaries in follicular phase
- muscles
- brown fat
- thymus
- oncocytomas
Indium-111
-half life
- production
- decay
photopeak
- half life = 67 hours
- cyclotron
- electron capture
- 173 keV, 247 keV
agents used to treat bone pain due to breast or prostate mets
- Sr-89 chloride
- Sm153 EDTMP
- Ra-223 dichloride
absolute contraindications for Sr-89 and Sm-153 treatment
- pregnancy
- breast feeding
- renal failure (GFR <30)
Sm-89 chloride
- Metastron
- worst and oldest agent used to treat cancer related bone pain
- pure beta emitter
- high myelotoxicity
- binds to hydroxyapatite where bone turnover is the highest
- renal excretion
Sr-153
- Quadramet
- 2nd best agent for bone pain
- binds to hydroxyapatite where bone turnover is the highest
- beta decay, with 28% of decay gamma rays (103 keV)
- transient bone marrow suppression that recovers faster than Sr (6-8 weeks vs. 8-12 weeks)
- renal excretion
Ra-223
-Xofigo
- emits 4 alpha particles - ds DNA breaks
- absorbed into bone matrix at sites of active mineralization
- side effects are diarrhea, nausea, vomiting, fatigue
long half life (11.4 days)
Y-90
- pure beta emitter
- 175 keV and 185 kEV emissions can be used to image
- half life = 2.67 days
produced in generator
Tc-99
Rb-82
