NSAIDs Flashcards
Give ASA therapeutic doses of the ff: Analgesic Antipyretic Anti-inflammatory Antiplatelets
Analgesic 325 mg Q4 to 6 h
Antipyretic 325 to 650 mg Q4-6h PRN Anti-inflammatory 650-975 mg Q4-6h
Antiplatelets 81-325 mg daily
Platelet life of ASA
Platelet life 7-10 days
ASA analgesic MOA
Prostaglandin PGE2 thought to sensitize the nerve endings to the action of bradykinin, histamines and other chemical mediators, thus inflammatory process may cause analgesic action. Decrease of PGE2 synthesis represses the sensation of pain.
ASA antipyretic MOA
Prostaglandin PGE2 stimulation occurs when pyrogen an endogenous fever producing agents such as cytokines is released from the white blood cells that are activated by infection, hypersensitivity, malignancy or inflammation. Salicylates lower temperature by decreasing PGE2 synthesis.
ASA antiplatelet MOA
Irreversible platelet inhibition and inhibition of Cox-I & Cox-II action gives antiplatelets action
ASA anti inflammatory MOA
Cox-I, Cox-II and prostaglandin inhibition
A 45 yo man diagnosed with benign prostatic hyperplasia, and migraine prophylaxis. Which of the
following is the appropriate therapy for migraine prophylaxis?
A) Propranolol B) Nortriptyline C) Amitriptyline D) Sumatriptan
A
A 12 month old child swallowed acetaminophen 10 ml syrup. A panic mother contact pharmacy. What is the initial symptoms of acetaminophen overdose?
Vomiting
GI effects of Acetaminophen is due to inhibition of?
The most common SEs of salicylate are?
- inhibition of prostaglandin PGEs
- GI disturbances like nausea, vomiting, epigastric discomfort, peptic ulcers (dyspepsia, heart burn)
Which PG inhibits gastric secretion?
Which PG stimulates synthesis of protective mucosa in stomach and small intestine?
Prostacyclin PGI2 inhibit gastric secretion.
PGE2 and PGF2α stimulates synthesis of protective mucosa in stomach and small intestine.
Which NSAID has the highest incidence of (35 to 50%) of GI ulcers?
Indomethacin
