Nose Pathology Flashcards

1
Q

What are nasal polyps normally lined with?

A

respiratory epithelium

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2
Q

What could indicated that a nasal polyp is metaplastic?

A

if it is lined with squamous

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3
Q

What nasal symptoms does GPA present with?

A

congestion
septal perforation
multinucleated giant cells on histology

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4
Q

What are the benign tumours of the nose?

A

squamous paillomas
schneiderian papillomas
angiofibromas

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5
Q

What are the malignant tumours of the nose?

A

squamous cell carcinomas

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6
Q

What increases risk of sqamous cell carcinomas of the nose?

A

male

smoking

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7
Q

What are the 3 types of schneiderian papillomas? What type is the most common?

A

inverted - most common
exophytic
oncocytic

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8
Q

What populations are at most risk of schneiderian papillomas?

A

over 50

males

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9
Q

What can cause schneiderian papillomas?

A

HPV
smoking
organic solvents - welding

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10
Q

What is the main symptom of schneiderian papillomas?

A

blocked nose

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11
Q

Where do inverted and oncocytic schneiderian papillomas affect?

A

lateral walls and paranasal sinuses

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12
Q

Where do exophytic schneiderian papillomas affect?

A

nasal septum

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13
Q

Where are nasopharyngeal carcinomas common?

A

Far East

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14
Q

What are nasopharyngeal carcinomas associated with?

A

Epstein Barr Virus
volatile nitrosamines in food
formaldehyde

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15
Q

What are the histological signs of nasopharyngeal carcinomas?

A

keratinising or non keratinising squamous cells

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16
Q

What can the Epstein Barr Virus be associated with/cause?

A

Burkitts lymphoma
B cell lymphoma
Hodkins lymphoma

17
Q

What is the mode of action of the Epstein Barr Virus?

A

infects epithelial eclls of the oropharynx and B cells
hijacks and mimics the T cell response leading to proliferation and survival of B cells
encodes EBNA-2 which activates cyclin D and promotes transition from G0->G1 = proliferation

18
Q

What is the Epstein Barr virus largely mediated by?

A

latent membrane prokin 1