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HEMATOLOGY (HARR) > Normocytic and normochromic anemias > Flashcards

Normocytic and normochromic anemias Flashcards

1
Q

Hypersplenism is characterized by:
A. Polycythemia
B. Pancytosis
C. Leukopenia
D. Myelodysplasia

A

C

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1
Q

Hypersplenism is characterized by:
A. Polycythemia
B. Pancytosis
C. Leukopenia
D. Myelodysplasia

A
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2
Q

Which of the following organs is responsible for
the “pitting process” for RBCs?
A. Liver
B. Spleen
C. Kidney
D. Lymph nodes

A

B

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3
Q

Spherocytes differ from normal red cells in all of
the following except:
A. Decreased surface to volume
B. No central pallor
C. Decreased resistance to hypotonic saline
D. Increased deformability

A

D

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4
Q

Which of the following is not associated with
hereditary spherocytosis?
A. Increased osmotic fragility
B. An MCHC greater than 36%
C. Intravascular hemolysis
D. Extravascular hemolysis

A

C

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5
Q

Which of the following disorders has an increase
in osmotic fragility?
A. Iron deficiency anemia
B. Hereditary elliptocytosis
C. Hereditary stomatocytosis
D. Hereditary spherocytosis

A

D

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6
Q
  1. The anemia seen in sickle cell disease is usually:
    A. Microcytic, normochromic
    B. Microcytic, hypochromic
    C. Normocytic, normochromic
    D. Normocytic, hypochromic
A

C

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7
Q

Which is the major Hgb found in the RBCs of
patients with sickle cell trait?
A. Hgb S
B. Hgb F
C. Hgb A2
D. Hgb A

A

D

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8
Q

Select the amino acid substitution that is
responsible for sickle cell anemia.
A. Lysine is substituted for glutamic acid at the
sixth position of the α-chain
B. Valine is substituted for glutamic acid at the
sixth position of the β-chain
C. Valine is substituted for glutamic acid at
the sixth position of the α-chain
D. Glutamine is substituted for glutamic acid at
the sixth position of the β-chain

A

B

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9
Q

All of the following are usually found in Hgb C
disease except:
A. Hgb C crystals
B. Target cells
C. Lysine substituted for glutamic acid at the sixth
position of the β–chain
D. Fast mobility of Hgb C at pH 8.6

A

D

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10
Q

Which of the following hemoglobins migrates to
the same position as Hgb A2 at pH 8.6?
A. Hgb H
B. Hgb F
C. Hgb C
D. Hgb S

A

C

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11
Q

Which of the following electrophoretic results is
consistent with a diagnosis of sickle cell trait?
A. Hgb A: 40% Hgb S: 35% Hgb F: 5%
B. Hgb A: 60% Hgb S: 40% Hgb A2: 2%
C. Hgb A: 0% Hgb A2: 5% Hgb F: 95%
D. Hgb A: 80% Hgb S: 10% Hgb A2: 10%

A

B Electrophoresis at alkaline pH usually shows 50%–70% Hgb A, 20%–40% Hgb S, and normal levels of Hgb A2 in a patient with the sickle cell trait

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12
Q

In which of the following conditions will
autosplenectomy most likely occur?
A. Thalassemia major
B. Hgb C disease
C. Hgb SC disease
D. Sickle cell disease

A

D

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13
Q

Which of the following is most true of paroxysmal
nocturnal hemoglobinuria (PNH)?
A. It is a rare acquired stem cell disorder that results
in hemolysis
B. It is inherited as a sex-linked trait
C. It is inherited as an autosomal dominant trait
D. It is inherited as an autosomal recessive trait

A

A

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14
Q

Hemolytic uremic syndrome (HUS) is
characterized by all of the following except:
A. Hemorrhage
B. Thrombocytopenia
C. Hemoglobinuria
D. Reticulocytopenia

A

D

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15
Q

An autohemolysis test is positive in all the
following conditions except:
A. Glucose-6-phosphate dehydrogenase (G6PD)
deficiency
B. Hereditary spherocytosis (HS)
C. Pyruvate kinase (PK) deficiency
D. Paroxysmal nocturnal hemoglobinuria (PNH)

A

D

16
Q

Which antibody is associated with paroxysmal cold
hemoglobinuria (PCH)?
A. Anti-I
B. Anti-i
C. Anti-M
D. Anti-P

A

D

17
Q

All of the following are associated with
intravascular hemolysis except:
A. Methemoglobinemia
B. Hemoglobinuria
C. Hemoglobinemia
D. Decreased haptoglobin

A

A

18
Q

Autoimmune hemolytic anemia is best
characterized by which of the following?
A. Increased levels of plasma C3
B. Spherocytic red cells
C. Decreased osmotic fragility
D. Decreased unconjugated bilirubin

A

B

19
Q

“Bite cells” are usually seen in patients with:
A. Rh null trait
B. Chronic granulomatous disease
C. G6PD deficiency
D. PK deficiency

A

C

20
Q

The morphological classification of anemias is
based on which of the following?
A. M:E (myeloid:erythroid) ratio
B. Prussian blue stain
C. RBC indices
D. Reticulocyte count

A

C

21
Q

Which of the following is a common finding in
aplastic anemia?
A. A monoclonal disorder
B. Tumor infiltration
C. Peripheral blood pancytopenia
D. Defective DNA synthesis

A

C

22
Q

Congenital dyserythropoietic anemias (CDAs) are
characterized by:
A. Bizarre multinucleated erythroblasts
B. Cytogenetic disorders
C. Megaloblastic erythropoiesis
D. An elevated M:E ratio

A

A

23
Q

Microangiopathic hemolytic anemia is
characterized by:
A. Target cells and Cabot rings
B. Toxic granulation and Döhle bodies
C. Pappenheimer bodies and basophilic stippling
D. Schistocytes and nucleated RBCs

A

D

24
Q

Microangiopathic hemolytic anemia is
characterized by:
A. Target cells and Cabot rings
B. Toxic granulation and Döhle bodies
C. Pappenheimer bodies and basophilic stippling
D. Schistocytes and nucleated RBCs

A

D

25
Q

Which antibiotic(s) is (are) most often implicated
in the development of aplastic anemia?
A. Sulfonamides
B. Penicillin
C. Tetracycline
D. Chloramphenicol

A

D

25
Q

Which antibiotic(s) is (are) most often implicated
in the development of aplastic anemia?
A. Sulfonamides
B. Penicillin
C. Tetracycline
D. Chloramphenicol

A

D

26
Q

Sickle cell disorders are:
A. Hereditary, intracorpuscular RBC defects
B. Hereditary, extracorpuscular RBC defects
C. Acquired, intracorpuscular RBC defects
D. Acquired, extracorpuscular RBC defects

A

A

27
Q

Which of the following conditions may produce
spherocytes in a peripheral smear?
A. Pelger–Huët anomaly
B. Pernicious anemia
C. Autoimmune hemolytic anemia
D. Sideroblastic anemia

A

C

28
Q

A patient’s peripheral smear reveals numerous
NRBCs, marked variation of red cell morphology,
and pronounced polychromasia. In addition to a
decreased Hgb and decreased Hct values, what
other CBC parameters may be anticipated?
A. Reduced platelets
B. Increased MCHC
C. Increased MCV
D. Decreased red-cell distribution width (RDW)

A

C

29
Q

What red cell inclusion may be seen in the
peripheral blood smear of a patient
postsplenectomy?
A. Toxic granulation
B. Howell–Jolly bodies
C. Malarial parasites
D. Siderotic granules

A

B

30
Q

Reticulocytosis usually indicates:
A. Response to inflammation
B. Neoplastic process
C. Aplastic anemia
D. Red cell regeneration

A

D

30
Q

Reticulocytosis usually indicates:
A. Response to inflammation
B. Neoplastic process
C. Aplastic anemia
D. Red cell regeneration

A

D

30
Q

Reticulocytosis usually indicates:
A. Response to inflammation
B. Neoplastic process
C. Aplastic anemia
D. Red cell regeneration

A

D

31
Q

Hereditary pyropoikilocytosis (HP) is a red cell
membrane defect characterized by:
A. Increased pencil-shaped cells
B. Increased oval macrocytes
C. Misshapen budding fragmented cells
D. Bite cells

A

C

HEMATOLOGY (HARR) (11 decks)

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