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HEMATOLOGY (HARR) > Lymphoproliferative and Myeloproliferative Disorders > Flashcards

Lymphoproliferative and Myeloproliferative Disorders Flashcards

1
Q

Repeated phlebotomy in patients with
polycythemia vera (PV) may lead to the
development of:
A. Folic acid deficiency
B. Sideroblastic anemia
C. Iron deficiency anemia
D. Hemolytic anemia

A

C

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2
Q

Repeated phlebotomy in patients with
polycythemia vera (PV) may lead to the
development of:
A. Folic acid deficiency
B. Sideroblastic anemia
C. Iron deficiency anemia
D. Hemolytic anemia

A

C

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3
Q

In essential thrombocythemia, the platelets are:
A. Increased in number and functionally abnormal
B. Normal in number and functionally abnormal
C. Decreased in number and functional
D. Decreased in number and functionally abnormal

A

A

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4
Q

In essential thrombocythemia, the platelets are:
A. Increased in number and functionally abnormal
B. Normal in number and functionally abnormal
C. Decreased in number and functional
D. Decreased in number and functionally abnormal

A

A

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5
Q

Which of the following cells is considered
pathognomonic for Hodgkin’s disease?
A. Niemann–Pick cells
B. Reactive lymphocytes
C. Flame cells
D. Reed–Sternberg cells

A

D

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6
Q

. In myelofibrosis, the characteristic abnormal red
blood cell morphology is that of:
A. Target cells
B. Schistocytes
C. Teardrop cells
D. Ovalocytes

A

C

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7
Q

PV is characterized by:
A. Increased plasma volume
B. Pancytopenia
C. Decreased oxygen saturation
D. Absolute increase in total red cell mas

A

D

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8
Q

Features of secondary polycythemia include all of
the following except:
A. Splenomegaly
B. Decreased oxygen saturation
C. Increased red cell mass
D. Increased erythropoietin

A

A

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9
Q

The erythrocytosis seen in relative polycythemia
occurs because of:
A. Decreased arterial oxygen saturation
B. Decreased plasma volume of circulating blood
C. Increased erythropoietin levels
D. Increased erythropoiesis in the bone marrow

A

B

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10
Q

In PV, what is characteristically seen in the
peripheral blood?
A. Panmyelosis
B. Pancytosis
C. Pancytopenia
D. Panhyperplasia

A

B

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11
Q

The leukocyte alkaline phosphatase (LAP) stain on
a patient gives the following results
10(0) 48(1+) 38(2+) 3(3+) 1(4+)
Calculate the LAP score.
A. 100
B. 117
C. 137
D. 252

A

C

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12
Q

CML is distinguished from leukemoid reaction by
which of the following?
A. CML: low LAP; leukemoid: high LAP
B. CML: high LAP; leukemoid: low LAP
C. CML: high WBC; leukemoid: normal WBC
D. CML: high WBC; leukemoid: higher WBC

A

A

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13
Q

Which of the following occurs in idiopathic
myelofibrosis (IMF)?
A. Myeloid metaplasia
B. Leukoerythroblastosis
C. Fibrosis of the bone marrow
D. All of these options

A

D

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14
Q

What influence does the Philadelphia (Ph1)
chromosome have on the prognosis of patients
with chronic myelocytic leukemia?
A. It is not predictive
B. The prognosis is better if Ph1 is present
C. The prognosis is worse if Ph1 is present
D. The disease usually transforms into AML when
Ph1 is present

A

B

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14
Q

What influence does the Philadelphia (Ph1)
chromosome have on the prognosis of patients
with chronic myelocytic leukemia?
A. It is not predictive
B. The prognosis is better if Ph1 is present
C. The prognosis is worse if Ph1 is present
D. The disease usually transforms into AML when
Ph1 is present

A

B

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15
Q

Which of the following is (are) commonly found
in CML?
A. Many teardrop-shaped cells
B. Intense LAP staining
C. A decrease in granulocytes
D. An increase in basophils

A

D

16
Q

Which of the following is (are) commonly found
in CML?
A. Many teardrop-shaped cells
B. Intense LAP staining
C. A decrease in granulocytes
D. An increase in basophils

A

D

17
Q

In which of the following conditions does LAP
show the least activity?
A. Leukemoid reactions
B. Idiopathic myelofibrosis
C. PV
D. CML

A

D

18
Q

In which of the following conditions does LAP
show the least activity?
A. Leukemoid reactions
B. Idiopathic myelofibrosis
C. PV
D. CML

A

D

19
Q

In which of the following conditions does LAP
show the least activity?
A. Leukemoid reactions
B. Idiopathic myelofibrosis
C. PV
D. CML

A

D

20
Q

A striking feature of the peripheral blood of a
patient with CML is a:
A. Profusion of bizarre blast cells
B. Normal number of typical granulocytes
C. Presence of granulocytes at different stages of
development
D. Pancytopenia

A

C

21
Q

Which of the following is often associated with
CML but not with AML?
A. Infections
B. WBCs greater than 20.0 × 109/L
C. Hemorrhage
D. Splenomegaly

A

D

22
Q

Multiple myeloma and Waldenström’s
macroglobulinemia have all the following in
common except:
A. Monoclonal gammopathy
B. Hyperviscosity of the blood
C. Bence–Jones protein in the urine
D. Osteolytic lesions

A

D

23
Q

What is the characteristic finding seen in the
peripheral smear of a patient with multiple
myeloma?
A. Microcytic hypochromic cells
B. Intracellular inclusion bodies
C. Rouleaux
D. Hypersegmented neutrophils

A

C

24
Q

All of the following are associated with the
diagnosis of multiple myeloma except:
A. Marrow plasmacytosis
B. Lytic bone lesions
C. Serum and/or urine M component (monoclonal
protein)
D. Philadelphia chromosome

A

D

24
Q

All of the following are associated with the
diagnosis of multiple myeloma except:
A. Marrow plasmacytosis
B. Lytic bone lesions
C. Serum and/or urine M component (monoclonal
protein)
D. Philadelphia chromosome

A

D

25
Q

Multiple myeloma is most difficult to distinguish
from:
A. Chronic lymphocytic leukemia
B. Acute myelogenous leukemia
C. Benign monoclonal gammopathy
D. Benign adenoma

A

C

26
Q

The pathology of multiple myeloma includes
which of the following?
A. Expanding plasma cell mass
B. Overproduction of monoclonal
immunoglobulins
C. Production of osteoclast activating factor (OAF)
and other cytokines
D. All of these options

A

D

27
Q

Waldenström’s macroglobulinemia is a
malignancy of the:
A. Lymphoplasmacytoid cells
B. Adrenal cortex
C. Myeloblastic cell lines
D. Erythroid cell precursors

A

A

28
Q

Cells that exhibit a positive stain with acid
phosphatase and are not inhibited with tartaric
acid are characteristically seen in:
A. Infectious mononucleosis
B. Infectious lymphocytosis
C. Hairy cell leukemia
D. T-cell acute lymphoblastic leukemia

A

C

29
Q

The JAK2(V617F) mutation may be positive in
all of the following chronic myeloproliferative
disorders except:
A. Essential thrombocythemia
B. Idiopathic myelofibrosis
C. PV
D. CML

A

D

30
Q

The JAK2(V617F) mutation may be positive in
all of the following chronic myeloproliferative
disorders except:
A. Essential thrombocythemia
B. Idiopathic myelofibrosis
C. PV
D. CML

A

D

31
Q

The JAK2(V617F) mutation may be positive in
all of the following chronic myeloproliferative
disorders except:
A. Essential thrombocythemia
B. Idiopathic myelofibrosis
C. PV
D. CML

A

D

32
Q

All of the following are major criteria for the
2008 WHO diagnostic criteria for essential
thrombocythemia except:
A. Platelet count >450 × 109/L
B. Megakaryocyte proliferation with large and
mature morphology, and no or little granulocyte
or erythroid proliferation
C. Demonstration of JAK2(V617F) or other clonal
marker
D. Sustained platelet count >600 × 109/L

A

D

HEMATOLOGY (HARR) (11 decks)

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