Coagulation System Disorders Flashcards
The APTT is sensitive to a deficiency of which
clotting factor?
A. Factor VII
B. Factor X
C. PF3
D. Calcium
B
Which test result would be normal in a patient
with dysfibrinogenemia?
A. Thrombin time
B. APTT
C. PT
D. Immunologic fibrinogen level
D
Which test result would be normal in a patient
with dysfibrinogenemia?
A. Thrombin time
B. APTT
C. PT
D. Immunologic fibrinogen level
D
A patient with a prolonged PT is given intravenous
vitamin K. The PT corrects to normal after
24 hours. What clinical condition most likely
caused these results?
A. Necrotic liver disease
B. Factor X deficiency
C. Fibrinogen deficiency
D. Obstructive jaundice
D
Which factor deficiency is associated with a
prolonged PT and APTT?
A. X
B. VIII
C. IX
D. XI
A
Which factor deficiency is associated with a
prolonged PT and APTT?
A. X
B. VIII
C. IX
D. XI
A
A prolonged APTT is corrected with factor
VIII– deficient plasma but not with factor
IX–deficient plasma. Which factor is deficient?
A. V
B. VIII
C. IX
D. X
C
A prolonged APTT is corrected with factor
VIII– deficient plasma but not with factor
IX–deficient plasma. Which factor is deficient?
A. V
B. VIII
C. IX
D. X
C
Which of the following is a characteristic of classic
hemophilia A?
A. Prolonged bleeding time
B. Autosomal recessive inheritance
C. Mild to severe bleeding episodes
D. Prolonged PT
C
Refer to the following results:
PT = prolonged
APTT = prolonged
Platelet count = decreased
Which disorder may be indicated?
A. Factor VIII deficiency
B. von Willebrand’s disease
C. DIC
D. Factor IX deficiency
C
Which of the following is a predisposing condition
for the development of DIC?
A. Adenocarcinoma
B. Idiopathic thrombocytopenic purpura (ITP)
C. Post-transfusion purpura (PTP)
D. Heparin-induced thrombocytopenia (HIT
A
Which of the following is a predisposing condition
for the development of DIC?
A. Adenocarcinoma
B. Idiopathic thrombocytopenic purpura (ITP)
C. Post-transfusion purpura (PTP)
D. Heparin-induced thrombocytopenia (HIT
A
Factor XII deficiency is associated with:
A. Bleeding episodes
B. Epistaxis
C. Decreased risk of thrombosis
D. Increased risk of thrombosis
D
Factor XII deficiency is associated with:
A. Bleeding episodes
B. Epistaxis
C. Decreased risk of thrombosis
D. Increased risk of thrombosis
D
Factor XII deficiency is associated with:
A. Bleeding episodes
B. Epistaxis
C. Decreased risk of thrombosis
D. Increased risk of thrombosis
D
The following results were obtained on a patient:
normal platelet count and function, normal PT,
and prolonged APTT. Which of the following
disorders is most consistent with these results?
A. Hemophilia A
B. Bernard–Soulier syndrome
C. von Willebrand’s disease
D. Glanzmann’s thrombasthenia
A
The following results were obtained on a patient:
normal platelet count and function, normal PT,
and prolonged APTT. Which of the following
disorders is most consistent with these results?
A. Hemophilia A
B. Bernard–Soulier syndrome
C. von Willebrand’s disease
D. Glanzmann’s thrombasthenia
A
The following laboratory results were obtained
from a 40-year-old woman: PT = 20 sec; APTT =
50 sec; thrombin time = 18 sec. What is the most
probable diagnosis?
A. Factor VII deficiency
B. Factor VIII deficiency
C. Factor X deficiency
D. Hypofibrinogenemia
D
When performing a factor VIII activity assay, a
patient’s plasma is mixed with:
A. Normal patient’s plasma
B. Factor VIII deficient plasma
C. Plasma with a high concentration of factor VIII
D. Normal control plasma
B
The most suitable product for treatment of factor
VIII deficiency is:
A. Fresh frozen plasma
B. Factor VIII concentrate
C. Prothrombin complex concentrate
D. Factor V Leiden
B
Which of the following is associated with an
abnormal platelet aggregation test?
A. Factor VIII deficiency
B. Factor VIII inhibitor
C. Lupus anticoagulant
D. Afibrinogenemia
D
Which of the following is associated with an
abnormal platelet aggregation test?
A. Factor VIII deficiency
B. Factor VIII inhibitor
C. Lupus anticoagulant
D. Afibrinogenemia
D
Which of the following is associated with an
abnormal platelet aggregation test?
A. Factor VIII deficiency
B. Factor VIII inhibitor
C. Lupus anticoagulant
D. Afibrinogenemia
D
Refer to the following results:
PT = normal
APTT = prolonged
Bleeding time= increased
Platelet count = normal
Platelet aggregation to ristocetin = abnormal
Which of the following disorders may be
indicated?
A. Factor VIII deficiency
B. DIC
C. von Willebrand’s disease
D. Factor IX deficiency
C
Which results are associated with hemophilia A?
A. Prolonged APTT, normal PT
B. Prolonged PT and APTT
C. Prolonged PT, normal APTT
D. Normal PT and APTT
A
Which results are associated with hemophilia A?
A. Prolonged APTT, normal PT
B. Prolonged PT and APTT
C. Prolonged PT, normal APTT
D. Normal PT and APTT
A
Fibrin monomers are increased in which of the
following conditions?
A. Primary fibrinolysis
B. DIC
C. Factor VIII deficiency
D. Fibrinogen deficiency
B
Which of the following is associated with multiple
factor deficiencies?
A. An inherited disorder of coagulation
B. Severe liver disease
C. Dysfibrinogenemia
D. Lupus anticoagulant
B
Normal PT and APTT results in a patient with a
poor wound healing may be associated with:
A. Factor VII deficiency
B. Factor VIII deficiency
C. Factor XII deficiency
D. Factor XIII deficiency
D
Fletcher factor (prekallikrein) deficiency may be
associated with:
A. Bleeding
B. Thrombosis
C. Thrombocytopenia
D. Thrombocytosis
B
One of the complications associated with a severe
hemophilia A is:
A. Hemarthrosis
B. Mucous membrane bleeding
C. Mild bleeding during surgery
D. Immune-mediated thrombocytopenia
A
The most common subtype of classic von
Willebrand’s disease is:
A. Type 1
B. Type 2A
C. Type 2B
D. Type 3
A
A patient with a prolonged PT is given intravenous
vitamin K. The PT corrects to normal after
24 hours. What clinical condition most likely
caused these results?
A. Necrotic liver disease
B. Factor X deficiency
C. Fibrinogen deficiency
D. Obstructive jaundice
D
A prolonged APTT and PT are corrected when
mixed with normal plasma. Which factor is most
likely deficient?
A. VIII
B. V
C. XI
D. IX
B
