Normal Wound Healing Flashcards
What is Phase 1 of Wound Healing?
Inflammation Phase
What is Phase 2 of Wound Healing?
Proliferation Phase
What is Phase 3 of Wound Healing?
Maturation/Remodeling Phase
What is the goal of the Inflammatory Phase?
Bioburden control and clean wound bed to allow for transition to the proliferation phase
What are the cardinal signs of inflammation?
- Redness
- Increased Temperature
- Edema
- Pain
- Loss of Function
What are some key components that occurs during the inflammatory phase?
- Increased blood flow to the area + oxygen (vasodilation)
- Slowing down the spread of pathogens
What is the goal of the Proliferation Phase?
Restoration of vascular integrity, wound defect and epithelium
Components of the Proliferation Phase?
- Neovascularization; Angiogenesis
- Granulation
- Wound Contraction
- Epithelialization
What is Granulation?
Fibroblast depositing collagen matrix around the new vasculature.
- Beefy red and granular (VERY FRAGILE)
What is Wound Contraction?
Myofibroblasts exert tractional forces pulling wound margins together
What is Epitheliazation?
Reparation of the epidermis via keratinocyte migration.
How does Epithelization differ from Superficial, partial-thick and full-thickness wounds?
Superficial and Partial Thick: Edges and Dermal Appendages
Full Thickness: Wound Edges Only
What stops epithelialization?
Contact Inhibition: epithelial cells touch, ceasing migration.
What is Epibole?
Premature halting leading to rolled edges.
What is the goal of the Remodeling/Maturation Phase?
Reorganization of immature collagen and reestablish tensile strength.
