Noradrenergic transmission

Question 1

Which drug converts L-tyrosine to DOPA?

Answer 1

tyrosine hydroxylase

Question 2

DOPA to dopamine enzyme?

Answer 2

DOPA decarboxylase

Question 3

Dopamine to noradrenaline enzyme?

Answer 3

dopamine beta hydroxylase

Question 4

Noradrenaline to adrenaline enzyme?

Answer 4

phenylethanolamine n-methyl transferase

Question 5

What are the stages of NA metabolism?

Answer 5

Noradrenaline to DOMA by MAO and DOMA to VMA by COMT and aldehyde dehydrogenase

Question 6

Where are alpha1 found and what is the response?

Answer 6

vascular smooth muscle, vas deferens.

Contraction

Question 7

Where are alpha2 found and what is the response?

Answer 7

adrenergic nerve terminals

Decrease NA release

Question 8

Where are beta1 found and what is the response?

Answer 8

cardiac muscle

increase heart rate and force of contraction

Question 9

Where are beta2 found and what is the response?

Answer 9

cardiac blood vessels, skeletal muscle blood vessels, bronchial smooth muscle.
dilation and relaxation

Question 10

Where are beta3 found and what is the response?

Answer 10

adipose tissue

lipolysis

Question 11

alpha1 G protein type and second messenger

Answer 11

Gq

PIP2

Question 12

alpha2 G protein type and second messenger

Answer 12

Gi. inhibit adenylate cyclase

Question 13

Beta protein type and second messenger

Answer 13

Gs. stimulate adenylate cyclase

Question 14

Which drug directly prevents action of tyrosine hydroxylase?

Answer 14

alpha-methylparatyrosine

Question 15

Which drugs directly prevents action of dopa decarboxylase? 2

Answer 15

carbidopa, benserazide

Question 16

Which drug directly prevents action of dopamine beta hydroxylase?

Answer 16

disulfiram

Question 17

Which 2 drugs act at the presynaptic terminal, affecting storage?

Answer 17

reserpine, alpha methyl dopa

Question 18

Which drugs effect release at the presynaptic terminal?

Answer 18

bretylium, clonidine

Question 19

Which receptor does Prazosin act upon?

Answer 19

alpha 1

Question 20

what is the response of Prazosin and what is it used for?

Answer 20

decreased BP, used in hypertension

Question 21

Which receptor does labetolol act upon?

Answer 21

alpha/beta

Question 22

what are 3 beta adrenoceptor antagonists?

Answer 22

propranolol, atenolol, pindelol

Question 23

what are 3 examples of directly acting sympathomimetics and their clinical uses?

Answer 23

1. NA, used in cardiac arrest and shock
2. Adrenaline, cardiac arrest, anaphylactic shock
3. salbutamol, asthma, inhibition of premature labour

Question 24

How does the indirectly acting sympathomimetic tyramine work?

Answer 24

competes with NA for U1 and displaces NA from vesicles.

Question 25

How does the indirectly acting sympathomimetic amphetamine work?

Answer 25

competes with NA for U1, displaces NA from vesicles and inhibits MAO