Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Noradrenergic transmission > Flashcards

Noradrenergic transmission Flashcards

1
Q

Which drug converts L-tyrosine to DOPA?

A

tyrosine hydroxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

DOPA to dopamine enzyme?

A

DOPA decarboxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Dopamine to noradrenaline enzyme?

A

dopamine beta hydroxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Noradrenaline to adrenaline enzyme?

A

phenylethanolamine n-methyl transferase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the stages of NA metabolism?

A

Noradrenaline to DOMA by MAO and DOMA to VMA by COMT and aldehyde dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Where are alpha1 found and what is the response?

A

vascular smooth muscle, vas deferens.

Contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Where are alpha2 found and what is the response?

A

adrenergic nerve terminals

Decrease NA release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Where are beta1 found and what is the response?

A

cardiac muscle

increase heart rate and force of contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Where are beta2 found and what is the response?

A

cardiac blood vessels, skeletal muscle blood vessels, bronchial smooth muscle.
dilation and relaxation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Where are beta3 found and what is the response?

A

adipose tissue

lipolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

alpha1 G protein type and second messenger

A

Gq

PIP2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

alpha2 G protein type and second messenger

A

Gi. inhibit adenylate cyclase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Beta protein type and second messenger

A

Gs. stimulate adenylate cyclase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which drug directly prevents action of tyrosine hydroxylase?

A

alpha-methylparatyrosine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which drugs directly prevents action of dopa decarboxylase? 2

A

carbidopa, benserazide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which drug directly prevents action of dopamine beta hydroxylase?

A

disulfiram

17
Q

Which 2 drugs act at the presynaptic terminal, affecting storage?

A

reserpine, alpha methyl dopa

18
Q

Which drugs effect release at the presynaptic terminal?

A

bretylium, clonidine

19
Q

Which receptor does Prazosin act upon?

A

alpha 1

20
Q

what is the response of Prazosin and what is it used for?

A

decreased BP, used in hypertension

21
Q

Which receptor does labetolol act upon?

A

alpha/beta

22
Q

what are 3 beta adrenoceptor antagonists?

A

propranolol, atenolol, pindelol

23
Q

what are 3 examples of directly acting sympathomimetics and their clinical uses?

A
  1. NA, used in cardiac arrest and shock
  2. Adrenaline, cardiac arrest, anaphylactic shock
  3. salbutamol, asthma, inhibition of premature labour
24
Q

How does the indirectly acting sympathomimetic tyramine work?

A

competes with NA for U1 and displaces NA from vesicles.

25
Q

How does the indirectly acting sympathomimetic amphetamine work?

A

competes with NA for U1, displaces NA from vesicles and inhibits MAO

Pharmacology (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions