11. NMJ and autonomic ganglion Flashcards
1
Q
What can block choline reuptake at the NMJ?
A
hemicholinium 3
2
Q
What can block the uptake and storage of ACh in synaptic vesicles?
A
vesamicol
3
Q
What blocks Na+ channels and leads to no AP and no vesicle release?
A
TTX
4
Q
What blocks P/Q/N Ca2+ channels and leads to no vesicle release?
A
conatoxin
5
Q
What blocks K+ channels and causes MORE release?
A
dendrotoxin
6
Q
How does botulinum toxin prevent vesicle fusion?
A
it cleaves proteins involved in vesicle fusion (snap and snare ?)
7
Q
Example of an NMJ non-depolarising blocker
A
tubocurarine
8
Q
Example of NMJ depolarising blocker
A
suxamethonium
9
Q
4 examples of ganglionic non-depolarising blockers
A
kappa-bungarotoxin, trimethapan, hexamethonium and tubocurarine
10
Q
2 ganglionic depolarising blockers
A
nicotine and lobeline
