5. Pain and it's control

Question 1

What are the properties of FAST pain?

Answer 1

Sharp, prickling, short duration, well localised

Question 2

Aδ fibres properties? (FAST pain) diameter, conductance, myelination

Answer 2

myelinated
1-5 μm diameter
fast conductance (5-30 m/s)

Question 3

SLOW pain properties?

Answer 3

dull, diffuse, long lasting, poorly localised, burning.

Question 4

C fibres properties? diameter, conductance, myelination

Answer 4

un-myelinated,
0.1-1.5 diameter
slow conductance

Question 5

What are two endogenous ligands for opiod receptors?

Answer 5

Endorphins and enkaphalins

Question 6

Source for discovery of endogenous ligands for opioid receptors?

Answer 6

Hughes et al 1975

Question 7

In which areas are opioid peptides found?

Answer 7

areas associated with nociception - PAG, rostral ventral medulla.

Question 8

MOP distribution

Answer 8

CNS, periphery, cortex, thalamus.

Question 9

KOP distribution

Answer 9

hypothalamus, PAG, substantia gelatinosa.

Question 10

DOP distribution

Answer 10

pontine nuclei, olfactory bulbs, cortex.

Question 11

MOP actions? 3

Answer 11

Analgesic effects
Respiratory depression
Dependence

Question 12

DOP actions? 3

Answer 12

analgesia (but less than MOP)
Important in periphery
May regulate mood, seizures

Question 13

KOP actions? 4

Answer 13

Analgesia, sedation, dysphoria, hallucinations