8. Diabetes

Question 1

Short acting insulin preparations: Examples, onset, peak, duration?

Answer 1

humulin S, actrapid
onset 30 minutes
peak 2-4 hours
duration 8 hours

Question 2

intermediate insulin preparations: Examples, onset, peak, duration?

Answer 2

Insulatard, Humulin I
Onset 1-2 hours
Peak 4-12 hours
Duration 16-24 hours

Question 3

Long acting insulin preparations: Examples, onset, peak, duration?

Answer 3

Human ultratard, Humulin Zn
Onset 1-2 hours
Peak 4-12 hours
Duration 20-35 hours

Question 4

Analogue insulin preparations: Examples, onset, peak, duration?

Answer 4

Humalog, novorapid
Onset 0-15 mins
peak 1-2 hours
duration 4-6 hours

Question 5

How do statins work?

Answer 5

inhibit HMG-CoA reductase (rate limiting enzyme of mevalonate pathway) and stop mevalonate pathway of cholesterol synthesis

Question 6

Fibrates?

Answer 6

Increase HDL, lower LDL and triglyceride levels

Question 7

Orlistat mechanism…

Answer 7

inhibits pancreatic lipase, decreases fat absorption by 30%