3. Pharmacodynamics Flashcards
1
Q
Receptor activators (2)
A
Adrenaline, morphine
2
Q
Enzyme inhibitor
A
aspirin
3
Q
Enzyme false substrate
A
methyldopa
4
Q
Receptor blocker
A
tubocurarine
5
Q
Ion channel blockers
A
Local anaesthetics
6
Q
Ion channel modulators (2)
A
Diazepam, general anaesthetics
7
Q
Neurotransmitter uptake blocker
A
Prozac
8
Q
What are the 4 different types of receptors?
A
- Ligand gated ion channels (ionotropic)
- G protein coupled receptors (metabotropic)
- Kinase-linked.
- Nuclear - linked to gene transcription.
9
Q
How can responses be measured experimentally? (5 ways)
A
- Production of second messenger
- Muscle contraction.
- Electrophysiology.
- Inhibition of transmitter release.
- Changes in heart rate
10
Q
What is affinity?
A
how well a ligand binds to a receptor
11
Q
What is efficacy?
A
Measure of the response of the binding
12
Q
Potency =
A
Efficacy + affinity
13
Q
What are 4 things that cause desensitisation?
A
- Change to receptors (phosphorylation)
- loss of receptors (internalisation)
- Exhaustion of mediators
- Physiological adaptation - homeostatic response
14
Q
Which clinical agonists (2) used to increase heart rate and force of contraction?
A
Adrenaline and dopamine
15
Q
Which clinical agonist is used for asthma?
A
Salbutamol
