Non-nucleoside reverse transcriptase inhibitors Flashcards
What does NNRTI stand for?
Non-nucleoside reverse transcriptase inhibitor.
True or False: NNRTIs are used in the treatment of HIV.
True.
Name one common NNRTI.
Efavirenz.
What is the primary action of NNRTIs?
They inhibit the reverse transcriptase enzyme, preventing viral replication.
Fill in the blank: NNRTIs bind to the __________ site of reverse transcriptase.
allosteric.
What is a major adverse effect of NNRTIs?
Rash.
Multiple choice: Which of the following is NOT an NNRTI? A) Nevirapine B) Tenofovir C) Rilpivirine
B) Tenofovir.
What should clients be educated about regarding the timing of NNRTI administration?
NNRTIs should be taken at the same time each day to maintain consistent drug levels.
True or False: NNRTIs require monitoring of liver function tests.
True.
What is a common side effect of Efavirenz?
Central nervous system effects, such as dizziness or vivid dreams.
Fill in the blank: NNRTIs can cause __________ toxicity in some patients.
hepatotoxicity.
What should be monitored in patients taking NNRTIs for long-term therapy?
Viral load and CD4 count.
Multiple choice: Which of the following is a contraindication for NNRTI use? A) Pregnancy B) HIV infection C) Liver disease
A) Pregnancy.
What is the role of client education in NNRTI therapy?
To ensure adherence, manage side effects, and inform about drug interactions.
True or False: NNRTIs are effective against HIV-2.
False.
What is the mechanism of action for NNRTIs?
They bind non-competitively to reverse transcriptase, inhibiting its function.
List one drug interaction that can occur with NNRTIs.
Interactions with anticonvulsants like phenytoin.
Fill in the blank: NNRTIs should be taken __________ food.
with or without, depending on the specific drug.
What is the importance of adherence to NNRTI therapy?
To prevent the development of drug resistance.
Multiple choice: What is a potential skin-related adverse effect of NNRTIs? A) Acne B) Rash C) Psoriasis
B) Rash.
What is the recommended action if a patient experiences severe rash while on NNRTIs?
Discontinue the medication and notify the healthcare provider.
True or False: NNRTIs can be used as monotherapy for HIV.
False.
What is a common dosing frequency for NNRTIs?
Once daily.
Name a benefit of using NNRTIs in HIV treatment regimens.
They have a low pill burden due to once-daily dosing.
What should be done if a dose of NNRTI is missed?
Take it as soon as remembered, but do not double the dose if it’s close to the next scheduled dose.
Fill in the blank: NNRTIs should not be administered with __________.
certain antacids or supplements containing calcium or magnesium.
