Integrase inhibitors Flashcards
What are integrase inhibitors primarily used for?
Integrase inhibitors are primarily used for the treatment of HIV.
True or False: Integrase inhibitors work by blocking the integrase enzyme.
True
Name one common integrase inhibitor.
Raltegravir
What is the mechanism of action of integrase inhibitors?
Integrase inhibitors prevent the integration of viral DNA into the host cell’s genome.
Fill in the blank: Integrase inhibitors are typically administered __________.
orally
List one common adverse effect of integrase inhibitors.
Nausea
What serious adverse effect is associated with the use of integrase inhibitors?
Severe skin reactions
True or False: Integrase inhibitors can be taken with or without food.
True
What should patients be advised to do if they miss a dose of an integrase inhibitor?
Take the missed dose as soon as remembered, but skip if it’s almost time for the next dose.
Name a contraindication for the use of integrase inhibitors.
Hypersensitivity to the drug.
What is the recommended route of administration for integrase inhibitors?
Oral administration.
Multiple Choice: Which of the following is NOT a common side effect of integrase inhibitors? A) Headache B) Weight gain C) Diarrhea D) Insomnia
B) Weight gain
True or False: Integrase inhibitors can interact with certain antacids.
True
What should be monitored regularly in patients taking integrase inhibitors?
Liver function tests.
Fill in the blank: Integrase inhibitors can lead to __________ in some patients.
Muscle pain or weakness
What is the importance of adherence to integrase inhibitor therapy?
To prevent viral resistance and treatment failure.
True or False: Integrase inhibitors can be used in combination with other antiretroviral medications.
True
What is a key counseling point for patients taking integrase inhibitors?
Inform them about the importance of taking the medication at the same time every day.
Name one integrase inhibitor that is available as a single-tablet regimen.
Bictegravir
What should patients report immediately while on integrase inhibitors?
Any signs of allergic reactions or severe skin reactions.
Multiple Choice: Which of the following is a potential drug interaction with integrase inhibitors? A) Methadone B) Calcium supplements C) St. John’s Wort D) All of the above
D) All of the above
What is the role of integrase inhibitors in HIV treatment regimens?
They are used as part of a combination therapy to effectively control viral load.
True or False: Integrase inhibitors are effective against all strains of HIV.
False
What is a common dosing frequency for integrase inhibitors?
Once or twice daily, depending on the specific drug.
Fill in the blank: Patients taking integrase inhibitors should avoid __________ supplements.
Calcium or magnesium
