non-melanoma skin cancers

Question 1

most prevalent cutaneous neoplasm

Answer 1

BCC

Question 2

where does most basal cell carcinoma occur?

Answer 2

head and neck

Question 3

classic description of BCC

Answer 3

pearly papules containing dialted subepidermal blood vessels

Question 4

types of tx for BCC (4)

Answer 4

1. cryosurgery/ electrosurgery
2. mohs surgery
3. radiation4. 5-FU or imiquimod topical

Question 5

AD; mutation of PTCH gene on chromosome 9; presents with numerous BCC, epidermal cysts, palmoplantar pits, rib abnormalities

Answer 5

gorlin syndrome

Question 6

major cause of SCC

Answer 6

UV exposure

Question 7

what type of SCC is associated with high rate of metastasis?

Answer 7

SCC in burn scar or osteomyelitis (marjolin ulcer)

Question 8

risk of metastasis of SCC increases with? (4)

Answer 8

1. size >4 cm
2. depth
3. neurotropism
4. acantholytic pattern

Question 9

 rapidly developing; elderly; flesh colored, dome shaped nodules with a central keratin filled plug (looks like a crater)

Answer 9

keratoacanthoma

Question 10

under 1 cm in diameter; tan brown, red, rough, sandpaper like consistency

Answer 10

actinic keratosis

Question 11

what is bowen’s disease

Answer 11

Squamous cell carcinoma in situ

Question 12

Anogenital, HPV related, sexually active young adults; clusters of small reddish brown papules

Answer 12

bowenoid papulosis

Question 13

aggressive neuroendocrine tumor

Answer 13

merkel cell carcinoma

Question 14

elderly; firm solitary nodule w/ ulceration; actinicaly damaged areas (head/neck)

Answer 14

atypical fibroxanthoma

Question 15

pleomorphic spindle cell tumor w/ incr mitotic activity

Answer 15

atypical fibroxanthoma

Question 16

angiosarcoma occurs in what populations (3)

Answer 16

(1) elderly head and neck
(2) lymphedema assc’d (stewart treves syndrome)
(3) post irradiation

Question 17

angiosarcoma that presents in females who have undergone masectomy with axillary node dissection

Answer 17

stewart-treves syndrome