benign tumors of the skin

Question 1

round flat waxy coin like plaques, can be pigmented or non pigmented

Answer 1

seborrheic keratoses

Question 2

numerous seborrheic keratoses indicating an underlying visceral malignancy

Answer 2

leser-trelat sign

Question 3

fibrovascular core covered by benign squamous epithelium

Answer 3

fibroepithelial polyp - acrochordon

Question 4

Deep nodule that has a central punctum

Answer 4

epidermoid cyst

Question 5

single subcut nodule at birth on lateral aspect of upper eyelid; usu in kids

Answer 5

dermoid cyst

Question 6

AD mutation in keratin 17, in sternal, axillae, groin

Answer 6

steatocystoma multiplex

Question 7

AD mutation of PTEN, oral lesions, acral keratoses, macrocephaly; multiple trichilemmoma

Answer 7

cowden’s disease

Question 8

ppl with cowden’s disease are at high risk for what types of cancers

Answer 8

breast; thyroid

Question 9

solitary firm nodules on cheek before age 20

Answer 9

pilomatrixoma

Question 10

Multiple fibrofolliculomas, trichodiscomas, and acrochordons

Answer 10

Birt-Hogg-Dube Syndrome

Question 11

Birt-Hogg-Dube Syndrome is d/t mutation of what gene

Answer 11

BHD gene on chrom 17; encodes protein folliculin

Question 12

Birt-Hogg-Dube Syndrome is associated with waht diseases (2)

Answer 12

1. renal tumors

2. spontaneous pneumothorax

Question 13

benign, presents on head/neck, esp scalp; secondary tumors can arise within them

Answer 13

nevus sebaceous

Question 14

which type of benign tumor of sebaceous gland is assc’d with muir torre syndrome

Answer 14

sebaceous adenoma

Question 15

which syndrome is assc’d with HNPCC

Answer 15

muir torre syndrome

Question 16

mutated MSH2, defect in DNA mismatch repair gene; AD

Answer 16

muir torre syndrome

Question 17

pink/red nodule; females; appears on head & neck; tumor of sweat gland

Answer 17

cylindroma

Question 18

brooke spiegler syndrome is assc’d with what benign tumor of sweat gland?

Answer 18

cylindroma

Question 19

AD mutation of CYLD gene on chrom 16; familial cylindroma, milia, spiradenomas;

Answer 19

brooke spiegler syndrome

Question 20

turban tumor; jigsaw puzzle histology

Answer 20

cylindroma

Question 21

____xanthoma is the only clinical xanthoma with normal serum lipid levels

Answer 21

disseminated

Question 22

yellow brown papule/nodule solitary lesions on head/neck, in kids; spontaneously regresses

Answer 22

juvenile xanthogranuloma

Question 23

juvenile xanthogranuloma can be assc’d with what?

Answer 23

1. CML

2. NF

Question 24

touton giant cells

Answer 24

juvenile xanthogranuloma

Question 25

ground glass histiocytes

Answer 25

reticulohistiocytoma

Question 26

what is the most agressive of the o Langerhans cell histiocytosis adn should be tx’d with chemotx?

Answer 26

Acute Generalized LCH (Letterer-Siwe Disease)

Question 27

lytic skull lesions, diabetes insipidus, proptosis

Answer 27

Multifocal Chronic LCH (Hand-Schuller-Christian Disease)

Question 28

CD1a immunostain helpful in dx of what?

Answer 28

Langerhans cell histiocytosis

Question 29

heterogenous dermal neoplasms of fibroblasts and histiocytes; solitary firm tan-brown papules

Answer 29

Dermatofibroma

Question 30

most common connective tissue tumor

Answer 30

lipoma

Question 31

arise where peripheral nerve is severed and does not heal; clinically painful nodule

Answer 31

traumatic neuroma

Question 32

severe pain in sole of foot; often d/t high heels

Answer 32

morton’s neuroma

Question 33

mucosal neuromas ass;cd with what condition

Answer 33

MEN 2b

Question 34

solitary painless nodule on face in middle aged-elderly

Answer 34

palisaded encapsulated neuroma

Question 35

widely distributed, solitary painless subcut mass; encapsulated with Antoni A an B parts, hyalinized vessels, verocay body

Answer 35

schwannoma

Question 36

plexiform neurofibroma

Answer 36

NF1

Question 37

localized form of pigmented vilonodular synovitis; occurs in small joints; giant cells on pathology

Answer 37

giant cell tumor of tendon sheath

Question 38

myxoid degeneration of joint capsule or tendon sheath on wrist, hand, foot, ankle; can present with pain or weakness

Answer 38

ganglion cyst