benign tumors of the skin Flashcards
round flat waxy coin like plaques, can be pigmented or non pigmented
seborrheic keratoses
numerous seborrheic keratoses indicating an underlying visceral malignancy
leser-trelat sign
fibrovascular core covered by benign squamous epithelium
fibroepithelial polyp - acrochordon
Deep nodule that has a central punctum
epidermoid cyst
single subcut nodule at birth on lateral aspect of upper eyelid; usu in kids
dermoid cyst
AD mutation in keratin 17, in sternal, axillae, groin
steatocystoma multiplex
AD mutation of PTEN, oral lesions, acral keratoses, macrocephaly; multiple trichilemmoma
cowden’s disease
ppl with cowden’s disease are at high risk for what types of cancers
breast; thyroid
solitary firm nodules on cheek before age 20
pilomatrixoma
Multiple fibrofolliculomas, trichodiscomas, and acrochordons
Birt-Hogg-Dube Syndrome
Birt-Hogg-Dube Syndrome is d/t mutation of what gene
BHD gene on chrom 17; encodes protein folliculin
Birt-Hogg-Dube Syndrome is associated with waht diseases (2)
- renal tumors
2. spontaneous pneumothorax
benign, presents on head/neck, esp scalp; secondary tumors can arise within them
nevus sebaceous
which type of benign tumor of sebaceous gland is assc’d with muir torre syndrome
sebaceous adenoma
which syndrome is assc’d with HNPCC
muir torre syndrome
mutated MSH2, defect in DNA mismatch repair gene; AD
muir torre syndrome
pink/red nodule; females; appears on head & neck; tumor of sweat gland
cylindroma
brooke spiegler syndrome is assc’d with what benign tumor of sweat gland?
cylindroma
AD mutation of CYLD gene on chrom 16; familial cylindroma, milia, spiradenomas;
brooke spiegler syndrome
turban tumor; jigsaw puzzle histology
cylindroma
____xanthoma is the only clinical xanthoma with normal serum lipid levels
disseminated
yellow brown papule/nodule solitary lesions on head/neck, in kids; spontaneously regresses
juvenile xanthogranuloma
juvenile xanthogranuloma can be assc’d with what?
- CML
2. NF
touton giant cells
juvenile xanthogranuloma
ground glass histiocytes
reticulohistiocytoma
what is the most agressive of the o Langerhans cell histiocytosis adn should be tx’d with chemotx?
Acute Generalized LCH (Letterer-Siwe Disease)
lytic skull lesions, diabetes insipidus, proptosis
Multifocal Chronic LCH (Hand-Schuller-Christian Disease)
CD1a immunostain helpful in dx of what?
Langerhans cell histiocytosis
heterogenous dermal neoplasms of fibroblasts and histiocytes; solitary firm tan-brown papules
Dermatofibroma
most common connective tissue tumor
lipoma
arise where peripheral nerve is severed and does not heal; clinically painful nodule
traumatic neuroma
severe pain in sole of foot; often d/t high heels
morton’s neuroma
mucosal neuromas ass;cd with what condition
MEN 2b
solitary painless nodule on face in middle aged-elderly
palisaded encapsulated neuroma
widely distributed, solitary painless subcut mass; encapsulated with Antoni A an B parts, hyalinized vessels, verocay body
schwannoma
plexiform neurofibroma
NF1
localized form of pigmented vilonodular synovitis; occurs in small joints; giant cells on pathology
giant cell tumor of tendon sheath
myxoid degeneration of joint capsule or tendon sheath on wrist, hand, foot, ankle; can present with pain or weakness
ganglion cyst
