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Pharm Unit 3 Drugs > Non-Medical Drugs > Flashcards

Non-Medical Drugs Flashcards

1
Q

Nalmefene (Revex) Class

A

Opioid antagonist

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2
Q

N-acetylcysteine (Mucomyst) Class

A

Antioxidant

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3
Q

Cocaine Class

A

CNS stimulant

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4
Q

LSD Class

A

Schedule I Hallucinogen

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5
Q

Mescaline Class

A

Schedule I Hallucinogen

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6
Q

Psilocybin Class

A

Schedule I Hallucinogen

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7
Q

Phencyclidine (PCP) Class

A

Dissociative anesthetic

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8
Q

Marijuana (THC) Class

A

Cannabinoid

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9
Q

Anandamide Class

A

Endogenous cannabinoid

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10
Q

Dronabinol (Marinol) Class

A

Synthetic THC

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11
Q

Nabilone (Cesamet) Class

A

Synthetic THC

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12
Q

N-acetylcysteine (Mucomyst) MOA

A

Supplies sulfhydryl groups to glutathione; improves microcirculation, provides anti-inflammatory effect

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13
Q

Fomepizole (Antizol) MOA

A

Blocks alcohol dehydrogenase

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14
Q

Cocaine MOA

A

Blocks reuptake of dopamine, norepinephrine, and serotonin

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15
Q

LSD MOA

A

Agonist at 5HT2A receptors on Raphe cell body –> inhibition of Raphe Nuclei firing –> increased sensory input; partial dopamine agonist

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16
Q

Mescaline MOA

A

Agonist at 5HT2A receptors on Raphe cell body –> inhibition of Raphe Nuclei firing –> increased sensory input; partial dopamine agonist

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17
Q

Psilocybin MOA

A

Agonist at 5HT2A receptors on Raphe cell body –> inhibition of Raphe Nuclei firing –> increased sensory input; partial dopamine agonist

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18
Q

Phencyclidine (PCP) MOA

A

Antagonist of ion channel associated with NDMA receptor; agonist at mu opioid receptors

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19
Q

Amphetamines (Benzadrine) MOA

A

Indirect sympathomimetic (release biologic amines from nerve terminals in periphery and in CNS); dopamine most important

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20
Q

Marijuana (THC) MOA

A

Hits cannabinoid receptors (CB1, CB2: G-protein coupled receptors)

21
Q

Anandamide MOA

A

Hits cannabinoid receptors (CB1, CB2: G-protein coupled receptors)

22
Q

Dronabinol (Marinol) MOA

A

Hits cannabinoid receptors (CB1, CB2: G-protein coupled receptors)

23
Q

Nabilone (Cesamet) MOA

A

Hits cannabinoid receptors (CB1, CB2: G-protein coupled receptors)

24
Q

N-acetylcysteine (Mucomyst) Theurapeutics

A

Acetaminophen overdose

25
Q

Fomepizole (Antizol) Theurapeutics

A

Methanol & ethylene glycol poisoning

26
Q

Cocaine Theurapeutics

A

Topical anesthetic, combined vasoconstrictor and local anesthetic

27
Q

LSD Theurapeutics

A

Schedule I hallucinogen; model hallucinogen against which all others compared; limited studies in psychoanalysis, alcoholism, autistic children, and terminal cancer patients

28
Q

Amphetamines (Benzadrine) Theurapeutics

A

Narcolepsy, ADHD

29
Q

Marijuana (THC) Theurapeutics

A

Schedule I hallucinogen; anti-emetic, anti-nausea, and appetite stimulate for cancer chemotherapy and AIDS patients; analgesic for neuropathic pain; potentially: glaucoma, asthma, anxiolytic, migraine, and multiple sclerosis treatment

30
Q

Anandamide Theurapeutics

A

Endogenous cannabinoid

31
Q

Dronabinol (Marinol) Theurapeutics

A

Schedule III drug; anti-emetic, anti-nausea, and appetite stimulate for cancer chemotherapy and AIDS patients

32
Q

Nabilone (Cesamet) Theurapeutics

A

Schedule II drug; treatment-resistant nausea and vomiting, weight loss and anorexia in AIDS patients

33
Q

Nalmefene (Revex) SE

A

May produce a prolonged withdrawal state (nausea, vomiting, piloerection, yawning)

34
Q

Cocaine SE

A

Sympathetic effects; paranoia, aggression

35
Q

LSD SE

A

Bad trips (anxiety attack, panic attack), flashbacks, “street drug” lifestyle; no overdoses, birth defects, or chronic psychoses linked to LSD

36
Q

Phencyclidine (PCP) SE

A
  1. Violent behavior, coma, seizures, arrest; inexplicable psychoses 2. Dissociation, confusion, ataxia, marked nystagmus
37
Q

Amphetamines (Benzadrine) SE

A
  1. Vasospasm leading to possible stroke or MI, arrhythmia, weight loss (anorectic effect) 2. Tremor, anxiety, irritability, confusion, possibly paranoid state
38
Q

Marijuana (THC)

A
  1. Vasodilation –> tachycardia, dilation of conjunctival vessels, bronchodilation, decreased intraocular pressure, hunger 2. May impair reproductive function in adolescents; heavy use may impair development of very young users; possible respiratory damage due to tar
39
Q

Fomepizole (Antizol) Misc

A

Very expensive

40
Q

Cocaine Misc

A

Rapidly hydrolyzed by plasma cholinesterase; crack is the free base form

41
Q

LSD Misc

A

Oxidized in liver; cross tolerance with mescaline and psilocybin

42
Q

Mescaline Misc

A

Cross tolerance with LSD and psilocybin

43
Q

Psilocybin Misc

A

Cross tolerance with mescaline and LSD

44
Q

Phencyclidine (PCP) Misc

A

Long half-life due to being highly lipid soluble and having active metabolites

45
Q

Amphetamines (Benzadrine) Misc

A

Others: dextroamphetamine (Dexedrine), methamphetamine (Desoxyn), methylphenidate (Ritalin)

46
Q

Marijuana (THC) Misc

A

Active ingredient is delta-9-tetrahydrocannabinol; metabolized by P450, with chronic use inducing enzyme; highly lipid soluble

47
Q

Nabilone (Cesamet) Misc

A

Less psychoactive side effects than marijuana

48
Q

Nalmefene (Revex) Class

A

Opiod antagonist

Pharm Unit 3 Drugs (13 decks)

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