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Pharm Unit 3 Drugs > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

Phenelzine (Nardil) Class

A

MAOI

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2
Q

Phenelzine (Nardil) MOA

A

Irreversibly inhibit both MAOa and MAOb, Prevent breakdown of DA

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3
Q

Phenelzine (Nardil) Therpeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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4
Q

Phenelzine (Naardil) SE

A
  1. Hypertensive crisis (with tyramine-rich foods); serotonin syndrome (MAOI + SSRI); agitation (rare), delerium –> seizures
  2. Anticholinergic, orthostatic hypotension, sexual dysfunction, weight gain, sedation
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5
Q

Desipramine (Norpramin) CLass

A

TCA

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6
Q

Desipramine (Norpramin) MOA

A

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

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7
Q

Desipramine (Norpramin) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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8
Q

Desipramine (Norpramine) SE

A
  1. Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)
  2. Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
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9
Q

Desipramine (Norpramine) MIsc

A

Not very safe; rarely used anymore

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10
Q

Imipramine (Tofranil) Class

A

TCA

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11
Q

Imipramine (Tofranil) MOA

A

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

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12
Q

Imipramine (Tofranil) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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13
Q

Imipramine (Tofranil) SE

A
  1. Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)
  2. Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
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14
Q

Imipramine (Tofranil) Misc

A

Not very safe; rarely used anymore; forms active metabolite (desipramine)

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15
Q

Amitriptyline (Elavil) Class

A

TCA

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16
Q

Amitriptyline (Elavil) MOA

A

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

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17
Q

Amitriptyline (Elavil) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; prevention of tension headaches, migraines

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18
Q

Amytriptyline (elavil) SE

A
  1. Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)
  2. Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
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19
Q

Amytriptyline (Elavil) Misc

A

Not very safe; rarely used anymore; forms active metabolite (nortriptyline)

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20
Q

Nortriptyline (Pamelor) Class

A

TCA

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21
Q

Nortriptyline (Pamelor) MOA

A

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

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22
Q

Nortriptyline (Pamelor) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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23
Q

Nortriptyline (Pamleor) SE

A
  1. Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)
  2. Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
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24
Q

Nortriptyline (Pamelor) Misc

A

Not very safe; rarely used anymore

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25
Q

Fluoxetine (Prozac) Class

A

SSRI

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26
Q

Fluoxetine (Prozac) MOA

A

Inhibit reuptake of 5-HT (and NE to lesser extent)

27
Q

Fluoxetine (Prozac) Therpeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; pre-menstrual dystrophic disorder

28
Q

Fluoxetine (Prozac) SE

A
  1. Serotonin syndrome (with MAOIs)

2. Fewer than tricyclics; mostly nausea, decreased sexual function

29
Q

Fluoxetine (Prozac) Misc

A

Potent P450 inhibitor; forms active metabolite (norfluoxetine)

30
Q

Paroxetine (Paxil) Class

A

SSRI

31
Q

Paroxetine (Paxil) MOA

A

Inhibit reuptake of 5-HT (and NE to lesser extent)

32
Q

Paroxetine (Paxil) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

33
Q

Paroxetine (Paxil) SE

A
  1. Serotonin syndrome (with MAOIs)

2. Fewer than tricyclics; mostly nausea, decreased sexual function

34
Q

Paroxetine (Paxil) Misc

A

Potent P450 inhibitor

35
Q

Sertraline (Zoloft) Class

A

SSRI

36
Q

Sertraline (Zoloft) MOA

A

Inhibit reuptake of 5-HT (and NE to lesser extent)

37
Q

Sertraline (Zoloft) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

38
Q

Sertraline (Zoloft) SE

A
  1. Serotonin syndrome (with MAOIs)

2. Fewer than tricyclics; mostly nausea, decreased sexual function

39
Q

Escitalopram (Lexapro) Class

A

SSRI

40
Q

Escitalopram (Lexapro) MOA

A

Inhibit reuptake of 5-HT (and NE to lesser extent)

41
Q

Escitalopram (Lexapro) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

42
Q

Escitalopram (Lexapro) SE

A
  1. Serotonin syndrome (with MAOIs)

2. Fewer than tricyclics; mostly nausea, decreased sexual function

43
Q

Citalopram (Celexa) Class

A

SSRI

44
Q

Citalopram (Celexa) MOA

A

Inhibit reuptake of 5-HT (and NE to lesser extent)

45
Q

Citalopram (Celexa) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

46
Q

Citalopram (Celexa) SE

A
  1. Serotonin syndrome (with MAOIs)

2. Fewer than tricyclics; mostly nausea, decreased sexual function

47
Q

Duloxetine (Cymbalta) Class

A

SNRI

48
Q

Duloxetine (Cymbalta) MOA

A

Inhibits reuptake of 5-HT and NE

49
Q

Duloxetine (Cymbalta) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

50
Q

Venlafaxine (Effexor) CLass

A

SNRI

51
Q

Venlafaxine (Effexor) MOA

A

Inhibits reuptake of 5-HT and NE

52
Q

Venlafaxine (Effexor) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

53
Q

Bupropion (Wellbutrin) Class

A

Atypical

54
Q

Bupropion (Wellbutrin) MOA

A

Blocks DA and NE reuptake

55
Q

Bupropion (Wellbutrin) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; maintain nicotine abstinence in quitting smokers

56
Q

Bupropion (Wellbutrin) SE

A

Lowers seizure threshold

57
Q

Mirtazapine (Remeron) Class

A

Atypical

58
Q

Mirtazapine (Remeron) MOA

A

5HT2a antagonists; also inhibit 5HT reuptake

59
Q

Mirtazapine (Remeron) THerapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

60
Q

Lithium MOA

A

Unknown; lithium depletes secondary messengers IP3 and DAG, important in a-adrenergic and muscarinic-cholinergic transmission

61
Q

Lithium Therapeutics

A

Anti-manic/mood-stabilizing (bipolar); long-term cluster headache prevention

62
Q

Lithium SE

A
  1. If elevated levels: neurotoxicity, cardiac toxicity, renal dysfunction
  2. Drowsiness, weight gain, tremor, polydipsia, polyuria
63
Q

Lithium Misc

A

Nausea and vomiting early sign of lithium OD; indomethacin and Na-depleting diuretics should be avoided (increase [Li])

Pharm Unit 3 Drugs (13 decks)

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