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Pharm Unit 3 Drugs > Anti-anxiety Drugs > Flashcards

Anti-anxiety Drugs Flashcards

1
Q

Misc for Benzodiazepines

A

“Ceiling effect” due to augmenting action of GABA

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2
Q

Diazepam (Valium) Class

A

Benzodiazepine

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3
Q

Clonazepam (Klonopin) Class

A

Benzodiazepine

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4
Q

Lorazepam (Ativan) Class

A

Benzodiazepine

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5
Q

Alprazolam (Xanax) Class

A

Benzodiazepine

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6
Q

Midazolam (Versed) Class

A

Benzodiazepine

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7
Q

Triazolam (Halcion) Class

A

Benzodiazepine

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8
Q

Zolpidem (Ambien) Class

A

Non-benzodiazepine receptor agonist

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9
Q

Flumazenil (Romazicon) Class

A

Benzodiazepine antagonist

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10
Q

Phenobarbitol Class

A

Barbiturate

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11
Q

Diazepam (Valium) MOA

A

GABAa agonist; binds between a1 and y2 subunits; half-life of 43 hours (active metabolites up to 100 hours)

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12
Q

Clonazepam (Klonopin) MOA

A

GABAa agonist; binds between a1 and y2 subunits; half-life of 20-50 hours

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13
Q

Lorazepam (Ativan) MOA

A

GABAa agonist; binds between a1 and y2 subunits; half-life of 14 hours

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14
Q

Alprazolam (Xanax) MOA

A

GABAa agonist; binds between a1 and y2 subunits; half-life of 12 hours

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15
Q

Midazolam (Versed) MOA

A

GABAa agonist; binds between a1 and y2 subunits; half-life of 1.9 hours

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16
Q

Triazolam (Halcion) MOA

A

GABAa agonist; binds between a1 and y2 subunits; half-life of 2.9 hours

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17
Q

Zolpidem (Ambien) MOA

A

BDZ-1 selective agonist

18
Q

Flumazenil (Romazicon) MOA

A

Competitive non-selective antagonist

19
Q

Phenobarbitol MOA

A

GABAa agonist (binds a or b subunit)

20
Q

Buspirone (Buspar) MOA

A

No GABAa interaction; may be partial agonist at 5HT1A

21
Q

Diazepam (Valium) Therapeutics

A

Short-term depression treatment; maintenance of bipolar; severe bipolar; anticonvulsant; muscle relaxant

22
Q

Clonazepam (Klonopin) Therapeutics

A

Short-term depression treatment; maintenance of bipolar; severe bipolar

23
Q

Lorazepam (Ativan) Therapeutics

A

Short-term depression treatment; maintenance of bipolar; severe bipolar; sedation; anticonvulsant; prevent withdrawal symptoms in alcoholics

24
Q

Alprazolam (Xanax) Therapeutics

A

Short-term depression treatment; maintenance of bipolar; severe bipolar; sedation

25
Q

Midazolam (Versed) Therapeutics

A

Anesthesia (calming effects, production of anterograde amnesia)

26
Q

Triazolam (Halcion) Therapeutics

A

Short-term depression treatment; maintenance of bipolar; severe bipolar; induce sleep

27
Q

Zolpidem (Ambien) Therapeutics

A

Sedation and hypnosis without muscle relaxation or anticonvulsant activity

28
Q

Flumazenil (Romazicon) Therapeutics

A

Benzodiazapine overdose

29
Q

Phenobarbitol Therapeutics

A

Antiepileptic, anticonvulsant

30
Q

Buspirone (Buspar) Therapeutics

A

Anxiolytic without marked sedation

31
Q

Diazepam (Valium) SE

A

Daytime sedation and drowsiness, anterograde amnesia, synergistic depression of CNS with other drugs, pyschologic and physiologic dependence (chronic use)

32
Q

Clonazepam (Klonopin) SE

A

Daytime sedation and drowsiness, anterograde amnesia, synergistic depression of CNS with other drugs, pyschologic and physiologic dependence (chronic use)

33
Q

Lorazepam (Ativan) SE

A

Daytime sedation and drowsiness, anterograde amnesia, synergistic depression of CNS with other drugs, pyschologic and physiologic dependence (chronic use)

34
Q

Alprazolam (Xanax) SE

A

Daytime sedation and drowsiness, anterograde amnesia, synergistic depression of CNS with other drugs, pyschologic and physiologic dependence (chronic use)

35
Q

Midazolam (Versed) SE

A

Daytime sedation and drowsiness, anterograde amnesia, synergistic depression of CNS with other drugs, pyschologic and physiologic dependence (chronic use)

36
Q

Triazolam (Halcion) SE

A

Daytime sedation and drowsiness, anterograde amnesia, synergistic depression of CNS with other drugs, pyschologic and physiologic dependence (chronic use)

37
Q

Zolpidem (Ambien) SE

A

Sleep-walking; next morning impairment

38
Q

Flumazenil (Romazicon) SE

A

Withdrawal (may be life-threatening); seizures in mixed overdoses

39
Q

Phenobarbitol SE

A

Daytime sedation and drowsiness, dose-dependent depression of CNS, pyschologic and physiologic dependence (chronic use)

40
Q

Flumazenil (Romazicon)

A

Non uniform in reversal of respiratory depression

41
Q

Phenobarbital

A

Abrupt withdrawal life-threatening

Pharm Unit 3 Drugs (13 decks)

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