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Pharm Unit 3 Drugs > Narcotics > Flashcards

Narcotics Flashcards

1
Q

Other SE for all opioids

A

Dry mouth, nausea/vomiting, sedation, sweating; dreams, dysphoria, delerium, myoclonus, seizures, pruritis, urticaria, urinary incontinence

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2
Q

Morphine Class

A

Opioid

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3
Q

Codeine Class

A

Opioid

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4
Q

Tramadol (Ultram) Class

A

Opioid

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5
Q

Fentanyl (Duragesic) Class

A

Opioid

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6
Q

Methadone (Methadose) Class

A

Opioid

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7
Q

Oxycodone Class

A

Opioid

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8
Q

Meperidine (Demerol) Class

A

Opioid

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9
Q

Loperamide (Imodium) Class

A

Opioid

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10
Q

Diphenoxylate (Lomotil) Class

A

Opioid

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11
Q

Naloxone (Narcan) Class

A

Opioid antagonist

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12
Q

Naltrexone (Revia) Class

A

Opioid antagonist

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13
Q

Morphine MOA

A

Mu-opioid receptor agonist

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14
Q

Codeine MOA

A

Mu-opioid receptor agonist (low receptor affinity); demethylated to form morphine (10% of oral ingestion, via CYP2D6)

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15
Q

Tramadol (Ultram) MOA

A

Mu opioid receptor agonist (weak); some NE/5HT uptake inhibition (leading to analgesia); synthetic codeine analog

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16
Q

Fentanyl (Duragesic)MOA

A

Mu-opioid receptor agonist (strong); highly lipid-soluble

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17
Q

Methadone (Methadose) MOA

A

Mu-opioid receptor agonist

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18
Q

Oxycodone MOA

A

Mu-opioid receptor agonist

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19
Q

Meperidine (Demerol) MOA

A

Mu-opioid receptor agonist

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20
Q

Loperamide (Imodium) MOA

A

Slows peristalsis via opioid receptors in intestine, and possibly decreased GI secretion

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21
Q

Diphenoxylate (Lomotil) MOA

A

Slows peristalsis via opioid receptors in intestine, and possibly decreased GI secretion

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22
Q

Naloxone (Narcan) MOA

A

Competitive mu-, delta-, and kappa-opioid receptor antagonist

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23
Q

Naltrexone (Revia)MOA

A

Mu-opioid receptor antagonist

24
Q

Morphine Therapeutics

A

Severe analgesia, mood alteration, antitussive, sedation

25
Q

Codeine Therapeutics

A

Moderate analgesia, antitussive (found in many cough medicines)

26
Q

Tramadol (Ultram)Therapeutics

A

Moderate (not severe) analgesia

27
Q

Fentanyl (Duragesic) Therapeutics

A

Severe analgesia after identification of dose level via other opiod (e.g., morphine)

28
Q

Methadone (Methadose) Therapeutics

A

Chronic, severe pain; treatment of heroin and opiod addicts

29
Q

Oxycodone Therapeutics

A

Moderate to severe analgesia

30
Q

Meperidine (Demerol) Therapeutics

A

Don’t use this

31
Q

Loperamide (Imodium) Therapeutics

32
Q

Diphenoxylate (Lomotil) Therapeutics

33
Q

Naloxone (Narcan) Therapeutics

A

Acute opioid toxicity (depressed RR best predicts reponse)

34
Q

Naltrexone (Revia) Therapeutics

A

Alcoholism

35
Q

Morphine SE

A

Miosis, constipation, respiratory depression

36
Q

Codeine SE

A

Miosis, constipation, respiratory depression

37
Q

Tramadol (Ultram) SE

A

Miosis, constipation, respiratory depression

38
Q

Fentanyl (Duragesic) SE

A

Miosis, constipation, respiratory depression

39
Q

Methadone (Methadose) SE

A

Miosis, constipation, respiratory depression

40
Q

Oxycodone SE

A

Miosis, constipation, respiratory depression

41
Q

Meperidine (Demerol) SE

A

Miosis, constipation, respiratory depression; mental status changes and seizures (normeperidine)

42
Q

Loperamide (Imodium) SE

A

Miosis, constipation, respiratory depression

43
Q

Diphenoxylate (Lomotil) SE

A

Miosis, constipation, respiratory depression

44
Q

Naloxone (Narcan) SE

A

Can precipitate withdrawal (flu-like symptoms of nausea, vomiting, diarrhea; piloerection, yawning, irritability)

45
Q

Naltrexone (Revia) SE

A

May produce a prolonged withdrawal state (nausea, vomiting, piloerection, yawning)

46
Q

Morphine Misc

A

2 major active metabolites: M6 (more potent/active), M3 (little affinity); intraspinal administration possible

47
Q

Codeine Misc

A

10% of Caucasians unable to convert codeine to morphine (can still experience side effects, though)

48
Q

Tramadol (Ultram) Misc

A

1 metabolite: demethylated, more potent analgesic

49
Q

Fentanyl (Duragesic) Misc

A

IV, transdermal; do not change dose more than 1/week (long half-life); intraspinal administration possible

50
Q

Methadone (Methadose) Misc

A

90% bound to plasma protein, accumulates in tissues (thus, extended duration of action); do not change dose more than 1/week (long half-life)

51
Q

Oxycodone Misc

A

Oxycontin is extended release

52
Q

Meperidine (Demerol) Misc

A

1 metabolite: normeperidine

53
Q

Loperamide (Imodium) Misc

A

Meperidine congener

54
Q

Diphenoxylate (Lomotil) Misc

A

Meperidine congener

55
Q

Naloxone (Narcan) Misc

A

Continuous parenteral infusion, as lasts only 15-30 minutes (oral almost completely metabolized by liver); patient has normal mental status

Pharm Unit 3 Drugs (13 decks)

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