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Pharm Unit 3 Drugs > Headache Drugs > Flashcards

Headache Drugs Flashcards

1
Q

Analgesics MOA

A

Inhibition of COX (COX2 may be preferential)

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2
Q

Analgesics Therapeutics

A

Acute treatment of moderate migraine (combination of acetaminophen, aspirin, and caffeine); acute treatment of tension headaches

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3
Q

Barbiturates Therapeutics

A

Acute treatment of migraines; use when more traditional therapies unavailable or contraindicated

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4
Q

Barbiturates SE

A

Drowsiness, dizziness

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5
Q

Barbiturates Misc

A

Use limited to 2-3 times per week

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6
Q

Opioids Therapeutics

A

Acute treatment of migraines; patients with infrequent headaches; generally, for patients who wake up with a headache

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7
Q

Opioids Misc

A

Use less than 2 days per week; pregnant women may use codeine or meperidine with caution

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8
Q

Corticosteroids Therapeutics

A

Acute treatment of migraines; migraine, prolonged headache syndromes (e.g., chronic daily headache); rescue treatment of cluster headache

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9
Q

Corticosteroids Misc

A

Chronic medicaton/overuse most common cause of chronic daily headaches

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10
Q

Ergotamines MOA

A

Vasoconstriction possibly; may also act as a 5HT agonist in trigeminovascular pathway

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11
Q

Ergotamines Therapeutics

A

Acute treatment of migraines

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12
Q

Ergotamines SE

A

Nausea, dizziness, paresthesia, chest pain, abdominal cramps

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13
Q

Ergotamines MIsc

A

Contraindicated in women planning pregnancy, uncontrolled HTN, sepsis, renal or hepatic failure, vascular disease

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14
Q

DHE (Migranal) MOA

A

Vasoconstriction possible; mainly act as a 5HT agonist in trigeminovascular pathway

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15
Q

DHE (Migranal) Therapeutics

A

Acute treatment of migraines; less likely to cause rebound headache than ergotamines; acute treatment of cluster headaches; short-term prevention of cluster headaches (along with steroids)

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16
Q

DHE (Migranal) SE

A
  1. Nausea (less likely than ergotamines), dizziness, paresthesia, chest pain, abdominal cramps
17
Q

DHE (Migranal) Misc

A

Contraindicated in women planning pregnancy, uncontrolled HTN, sepsis, renal or hepatic failure, vascular disease; injectable

18
Q

Sumatriptan (Imitrex) Class

19
Q

Sumatriptan (Imitrex) MOA

A

Selective 5HT1b-d agonists; penetration of CNS, constriction of extracerebral intracranial vessels, inhibition of trigeminovascular system

20
Q

Sumatriptan (Imitrex) Therapeutics

A

Acute treatment of migraines (premier option); also effective for photo/phonophobia, nausea and vomiting; acute treatment of cluster headaches

21
Q

Sumatriptan (Imitrex) SE

A
  1. Flushing, tingling, dizziness, chest discomfort (noncardiac)
22
Q

Sumatriptan (Imitrex) Misc

A

Contraindicated in vascular disease (including Prinzmetal), uncontrolled HTN, complicated migraine; injectable (suma)

23
Q

Onabotulinum toxin (Botox) MOA

A

Unknown (possibly decreased afferent stimulation of trigeminovascular system, or downregulation of sensory and parasympathetic receptors)

24
Q

Onabotulinium toxin (Botox) Therapeutics

A

Acute treatment of chronic migraine headaches

25
Onabotulinium Toxin (Botox) SE
Injection site pain, headache, neck weakness, ptosis
26
TCA Therapeutics
Migraine prevention, tension headache prevention
27
TCA SE
Dry mouth, constipation, weight gain, cardiac toxicity, orthostatic hypotension
28
TCA Misc
Amitriptyline, protriptyline, nortriptyline
29
SSRIs Therapeutics
Migraine prevention, tension headache prevention
30
SSRIs SE
Weight gain, sexual dysfunction, headache
31
SSRI Misc
Fluoxetine, paroxetine, sertraline
32
Beta-blockers Therapeutics
Migraine prevention (only propranolol and timolol FDA approved)
33
Beta-blockers SE
Drowsiness, depression, decreased libido, hypotension, memory disturbance
34
Beta-blockers Misc
Propranolol, timolol, nadolol, atenolol; contraindicated in asthma, diabetes, CHF, or Raynaud's
35
Calcium CHannel Blockers Therapeutics
Migraine prevention; particularly useful in prolonged or disabling aura, or complicated migraine syndromes (e.g., hemiplegic migarine); long-term prevention of cluster headaches
36
Calcium Channel blockers SE
Constipation, dizziness
37
Calcium CHannel Blockers Misc
Verapamil most commonly used
38
Oxygen Therapeutics
Acute treatment of cluster headaches
39
Oxygen Misc
Rebound can occur when oxygen stopped

Pharm Unit 3 Drugs (13 decks)

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