non-infectious

Question 1

amyloidosis

Answer 1

affects mice
primary-age
secondary- chronic inflammation, experiment

C/S- subclinical
histo- interstitial deposits of acellular pink stuff (liver, spleen, kidney, intestine)

Question 2

barbering

Answer 2

intact coat, non itchy patches of hair loss w no skin lesions
tx- separate barber from group

Question 3

fight wounds

Answer 3

some strains fight more-> separate mean one, tx w topical abx, cull
minimize stress transfer nest when changing cages

Question 4

ulcerative dermatitis

Answer 4

multifactorial-> diet genetic, season
C/S- moist dermatitis
dx- r/o parasites
tx- trim nails, topical ointment

Question 5

ring tail

Answer 5

annular constriction-> localized edema-> dry gangrene
low humidity, diet deficiency
ddx- tail snip, adverse rxn from injection
tx- lanolin, increase humidity, amp

Question 6

malocclusion

Answer 6

weight loss, hunched posture
tx- trim teeth, cull

Question 7

eye conditions

Answer 7

micropthalmia/anopthalmia: congenital, no tx
cataracts- strain specific or trauma
blepharitis- swelling, squinting tx flushing lube abx, nt
corneal ulceration- squinting from traume high ammonia tx with ointment, enucleation
bupthalmos/exopthalmos- enlarged globe-> glaucoma, mass, strain specific tx monitor, cull
retinal degneration-> genetic or environmental (RD1 gene)

Question 8

lymphoma

Answer 8

follicular b cell
subclinical-> abd distension, big spleen, LN
dx- histo

Question 9

mammary tumours

Answer 9

mouse mammary tumour virus, genetics, chemicals, radiation, hormones
C/S- well defined mass
dx- histology (adenocarcinoma most common)

Question 10

chronic progressive nephropathy

Answer 10

rats, varies w age (>1y), strain (SD), sex (M), high protein diet
C/S- weight loss, proteinuria, high CRE
dx- pitted kidneys, dilated tubules on histo
can get secondary hyperparathyroidism

Question 11

mammary tumours in rats

Answer 11

most common tumour
fibroadenoma
older females, SD, overfeeding
C/S- firm lobluated mass
dx- surrounded by CT on histo
tx- sx

Question 12

pituitary gland tumour

Answer 12

rats-. SD, older, unmated
chromophobe adenoma
dx- soft dark mass

Question 13

lymphocytic leukemia

Answer 13

f344 large granular
C/S- anemia, icterus, weight loss
dx- high WBC, big spleen, liver lymphocytes on histo

Question 14

zymbals gland tumours

Answer 14

holocrine gland at base of ear
dx- lobulated ulcerated mass (adenoma or adenocarcinoma)

Question 15

hamster amyloidosis

Answer 15

> 15m, females, injection
C/S- edema, ascites
path- liver, kidney, adrenals. pale rough organs, amyloid on histo

Question 16

polycystic disease

Answer 16

hamsters, congenital
cysts in lymphatics (liver, epididymis, seminal vesicles)
C/S- abd distension
path- this walled cysts, clear fluid

Question 17

neoplasms hamsters

Answer 17

adrenocortical adenocarcinoma most common
lymphoma- multicentric
cutaneous-> alopecia, exfoliative skin. lymphocytes in dermis on histo

Question 18

scurvy

Answer 18

GPs
C/S- subclinical-> bruising, reluctant to move, swollen joints. vit C<0.55
path- hemorrhage in periosteum, growth plates deranged on histo
tx- feed 10-25mg/d, higher when pregnant, fresh foods

Question 19

pregnancy toxemia

Answer 19

GPs
preeclampsia- late preg, uteroplacental ischemia

fasting ketosis- last trimester

C/S- depression, acidosis, ketosis
path- big liver, yellow w foci, ulcers.

prevent w weight restriction

Question 20

metastatic mineralization

Answer 20

GPs >1y
low mg, high P
C/S- alopecia, stiffness, renal dz
path- mineralization of soft tissue and ribs

Question 21

urolithiasis/cystitis

Answer 21

predisposed w genetics
C/S- subclinical hematuria, dysuria, straining
dx- rads, urine culture
path- grit in bladder/urethra, stones (carbonate)
tx- sx, abx

Question 22

ovarian cysts

Answer 22

GPs 1-5y
C/S- anorexia, depression, abd distension, symmetrical hair,repro

Question 23

trichoepitheliomas

Answer 23

benign
C/S- mass on dorsum +/- ulceration
path- epithelial structures of hair bulbs on histo
tx- sx

Question 24

ulcerative pododermatitis

Answer 24

traumatic ulceration-> pressure necrosis
C/S- anorexia, weight loss, hunched posture, frequent shifting
tx- soft bedding, resting boards, topical zinc, iodine, abx

Question 25

vertebral fx

Answer 25

rabbits
L7- posterior paralysis, incontinence
dx- C/S, rads
tx- medical, euth

Question 26

gastric trichobezoar

Answer 26

rabbits
C/S- incidental, possible obstruction
path- gastric rupture, fatty liver
dx- palpation, rads, exlap
tx- mineral oil, pineapple juice, increase roughage

Question 27

mucoid enteropathy

Answer 27

predisposed factors- low fiber, intestinal flora, weanlings
C/S- acute anorexia, PD, decreased temp, rough coat, d+, death in 2-4d
path- stomach, SI distended
goblet cell hyperplasia on histo

Question 28

endometrial adenocarcinomas

Answer 28

rabbits, old females
malignant
C/S- repro failure
dx- imaging, necropsy
tx- ovariohysterectomy

Question 29

lymphosarcoma in rabbits

Answer 29

common <2y
tetrad of lesions-> big kidneys, spleen, liver, LN
retroviral infection, genetics

Question 30

ammonia toxicity

Answer 30

zebrafish
C/S- hyperactivity, death, anorexia
path- gill hyperplasia on histo
dx- water test
tx- reduce density, increase frequency of water change, add binders

Question 31

nitrite toxicity

Answer 31

high nitrobacter, nitrospira-> methemoglobin-> hypoxia
C/S- pale tan gills, increased RR
dx- water quality testing
tx- add chloride

Question 32

chlorine toxicity

Answer 32

causes gill necrosis, asphyxiation
C/S- extensive mucous, resp and acid base disturbance
dx- water testing
tx- remove with aeration, filter, chemical

Question 33

gas bubble disease

Answer 33

supersaturation of nitrogen/oxygen
C/S- gas bubbles in skin fins eyes
dx- C/S, wet mount
tx- aerate water

Question 34

egg associated inflammation

Answer 34

adult female zebrafish
egg retention
C/S- distended coelom, ulceration
path- solid mass in ovary
prevention

Question 35

dehydration/dessication

Answer 35

xenopus
C/S- dry dark skin, shock
tx- put in water with salt, IC fluids

Question 36

heavy metal toxins

Answer 36

Cu, Zn, Pb
high humidity, acidic
C/S- excess mucous, dyspnea, paralysis
prevention- water testing