non-infectious Flashcards
amyloidosis
affects mice
primary-age
secondary- chronic inflammation, experiment
C/S- subclinical
histo- interstitial deposits of acellular pink stuff (liver, spleen, kidney, intestine)
barbering
intact coat, non itchy patches of hair loss w no skin lesions
tx- separate barber from group
fight wounds
some strains fight more-> separate mean one, tx w topical abx, cull
minimize stress transfer nest when changing cages
ulcerative dermatitis
multifactorial-> diet genetic, season
C/S- moist dermatitis
dx- r/o parasites
tx- trim nails, topical ointment
ring tail
annular constriction-> localized edema-> dry gangrene
low humidity, diet deficiency
ddx- tail snip, adverse rxn from injection
tx- lanolin, increase humidity, amp
malocclusion
weight loss, hunched posture
tx- trim teeth, cull
eye conditions
micropthalmia/anopthalmia: congenital, no tx
cataracts- strain specific or trauma
blepharitis- swelling, squinting tx flushing lube abx, nt
corneal ulceration- squinting from traume high ammonia tx with ointment, enucleation
bupthalmos/exopthalmos- enlarged globe-> glaucoma, mass, strain specific tx monitor, cull
retinal degneration-> genetic or environmental (RD1 gene)
lymphoma
follicular b cell
subclinical-> abd distension, big spleen, LN
dx- histo
mammary tumours
mouse mammary tumour virus, genetics, chemicals, radiation, hormones
C/S- well defined mass
dx- histology (adenocarcinoma most common)
chronic progressive nephropathy
rats, varies w age (>1y), strain (SD), sex (M), high protein diet
C/S- weight loss, proteinuria, high CRE
dx- pitted kidneys, dilated tubules on histo
can get secondary hyperparathyroidism
mammary tumours in rats
most common tumour
fibroadenoma
older females, SD, overfeeding
C/S- firm lobluated mass
dx- surrounded by CT on histo
tx- sx
pituitary gland tumour
rats-. SD, older, unmated
chromophobe adenoma
dx- soft dark mass
lymphocytic leukemia
f344 large granular
C/S- anemia, icterus, weight loss
dx- high WBC, big spleen, liver lymphocytes on histo
zymbals gland tumours
holocrine gland at base of ear
dx- lobulated ulcerated mass (adenoma or adenocarcinoma)
hamster amyloidosis
> 15m, females, injection
C/S- edema, ascites
path- liver, kidney, adrenals. pale rough organs, amyloid on histo
polycystic disease
hamsters, congenital
cysts in lymphatics (liver, epididymis, seminal vesicles)
C/S- abd distension
path- this walled cysts, clear fluid
neoplasms hamsters
adrenocortical adenocarcinoma most common
lymphoma- multicentric
cutaneous-> alopecia, exfoliative skin. lymphocytes in dermis on histo
scurvy
GPs
C/S- subclinical-> bruising, reluctant to move, swollen joints. vit C<0.55
path- hemorrhage in periosteum, growth plates deranged on histo
tx- feed 10-25mg/d, higher when pregnant, fresh foods
pregnancy toxemia
GPs
preeclampsia- late preg, uteroplacental ischemia
fasting ketosis- last trimester
C/S- depression, acidosis, ketosis
path- big liver, yellow w foci, ulcers.
prevent w weight restriction
metastatic mineralization
GPs >1y
low mg, high P
C/S- alopecia, stiffness, renal dz
path- mineralization of soft tissue and ribs
urolithiasis/cystitis
predisposed w genetics
C/S- subclinical hematuria, dysuria, straining
dx- rads, urine culture
path- grit in bladder/urethra, stones (carbonate)
tx- sx, abx
ovarian cysts
GPs 1-5y
C/S- anorexia, depression, abd distension, symmetrical hair,repro
trichoepitheliomas
benign
C/S- mass on dorsum +/- ulceration
path- epithelial structures of hair bulbs on histo
tx- sx
ulcerative pododermatitis
traumatic ulceration-> pressure necrosis
C/S- anorexia, weight loss, hunched posture, frequent shifting
tx- soft bedding, resting boards, topical zinc, iodine, abx
vertebral fx
rabbits
L7- posterior paralysis, incontinence
dx- C/S, rads
tx- medical, euth
gastric trichobezoar
rabbits
C/S- incidental, possible obstruction
path- gastric rupture, fatty liver
dx- palpation, rads, exlap
tx- mineral oil, pineapple juice, increase roughage
mucoid enteropathy
predisposed factors- low fiber, intestinal flora, weanlings
C/S- acute anorexia, PD, decreased temp, rough coat, d+, death in 2-4d
path- stomach, SI distended
goblet cell hyperplasia on histo
endometrial adenocarcinomas
rabbits, old females
malignant
C/S- repro failure
dx- imaging, necropsy
tx- ovariohysterectomy
lymphosarcoma in rabbits
common <2y
tetrad of lesions-> big kidneys, spleen, liver, LN
retroviral infection, genetics
ammonia toxicity
zebrafish
C/S- hyperactivity, death, anorexia
path- gill hyperplasia on histo
dx- water test
tx- reduce density, increase frequency of water change, add binders
nitrite toxicity
high nitrobacter, nitrospira-> methemoglobin-> hypoxia
C/S- pale tan gills, increased RR
dx- water quality testing
tx- add chloride
chlorine toxicity
causes gill necrosis, asphyxiation
C/S- extensive mucous, resp and acid base disturbance
dx- water testing
tx- remove with aeration, filter, chemical
gas bubble disease
supersaturation of nitrogen/oxygen
C/S- gas bubbles in skin fins eyes
dx- C/S, wet mount
tx- aerate water
egg associated inflammation
adult female zebrafish
egg retention
C/S- distended coelom, ulceration
path- solid mass in ovary
prevention
dehydration/dessication
xenopus
C/S- dry dark skin, shock
tx- put in water with salt, IC fluids
heavy metal toxins
Cu, Zn, Pb
high humidity, acidic
C/S- excess mucous, dyspnea, paralysis
prevention- water testing
